Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5527171..5527828 Replicon chromosome
Accession NZ_CP060243
Organism Pseudomonas aeruginosa strain A-I-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A8G3IXE4
Locus tag I5155_RS26070 Protein ID WP_003098540.1
Coordinates 5527171..5527353 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I5155_RS26075 Protein ID WP_003124172.1
Coordinates 5527400..5527828 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5155_RS26040 5522754..5524481 - 1728 WP_034053197.1 terminase large subunit -
I5155_RS26045 5524485..5524967 - 483 WP_014602593.1 phage terminase small subunit P27 family -
I5155_RS26050 5525049..5525453 - 405 WP_023981182.1 HNH endonuclease -
I5155_RS26055 5525590..5526021 - 432 WP_171947066.1 hypothetical protein -
I5155_RS26060 5526039..5526656 - 618 WP_196332017.1 glycoside hydrolase family 19 protein -
I5155_RS26065 5526656..5526970 - 315 WP_015649339.1 phage holin, lambda family -
I5155_RS26070 5527171..5527353 + 183 WP_003098540.1 type II toxin-antitoxin system HicA family toxin Toxin
I5155_RS26075 5527400..5527828 + 429 WP_003124172.1 hypothetical protein Antitoxin
I5155_RS26080 5528127..5528684 - 558 WP_015980945.1 hypothetical protein -
I5155_RS26085 5528681..5528965 - 285 WP_023835928.1 hypothetical protein -
I5155_RS26090 5528962..5530359 - 1398 WP_033944544.1 AAA family ATPase -
I5155_RS26095 5530356..5531240 - 885 WP_191984976.1 ATP-binding protein -
I5155_RS26100 5531152..5531991 - 840 WP_033944546.1 helix-turn-helix domain-containing protein -
I5155_RS26105 5531988..5532218 - 231 WP_023124259.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6746.86 Da        Isoelectric Point: 11.0775

>T170126 WP_003098540.1 NZ_CP060243:5527171-5527353 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T170126 NZ_CP077086:4383594-4383869 [Pseudomonas zarinae]
ATGGAGTTGAAGTGGACCAGCAAGGCGCTTTCCGACATTGCTCGACTTTATGAATTTCTGGCGGCGGTGAATCAACCCGC
GGCCGCGCGAACAGTGCAACAACTCACGGCCGCGCCGACCTCTCTATTGGCCAACCCGCGCATTGGTGAACGCCTGGAAG
AGTTCGAACCTCGAGACGTGCGCAGAATCCAAGTGGGGCGCTACGAAATGCGCTATGAAATAGCCGGTTCCACCCTGTAC
CTGCTACGCCTGTGGCACACACGTGAGGATCGATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15770.97 Da        Isoelectric Point: 4.6562

>AT170126 WP_003124172.1 NZ_CP060243:5527400-5527828 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KVALWNEMIRRDMRKADLCRLLGIAQIQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT170126 NZ_CP077086:4383322-4383594 [Pseudomonas zarinae]
ATGACAACCACCGCGAAAACCCGGTCGGTCACAGCTCACGTCCCGGTGCACCTGGCCGAAAAAGTCGACCTGATGGCCGA
GCGCCTCGAGCGTTCCAGGAACTGGATCGTCAAACAAGCGCTATCTGCCTGGATCGAGCAGGAGGAGGAGCGAAGCCGCC
TGACCCATGAGGCCTTGGCCGATGTTGACGCCGGCCGAGTGATTGACCACCAGGCTGTCCAGGCTTGGGCCGATAGTCTC
AGCACCGACGCCCCGTTACCAGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References