Detailed information of TA system TA170125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4918190..4919448
• Replicon: chromosome
• Accession: NZ_CP060243
• Organism: Pseudomonas aeruginosa strain A-I-1

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: I5155_RS23155
• Protein ID: WP_003086331.1
• Coordinates: 4918190..4918945 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: I5155_RS23160
• Protein ID: WP_003086329.1
• Coordinates: 4919080..4919448 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5155_RS23145	4913361..4915904	+	2544	WP_033955245.1	acyl-homoserine-lactone acylase QuiP	-
I5155_RS23150	4916060..4917421	-	1362	WP_003120632.1	DNA recombination protein RmuC	-
I5155_RS23155	4918190..4918945	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
I5155_RS23160	4919080..4919448	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
I5155_RS23165	4919521..4920807	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
I5155_RS23170	4920863..4922452	-	1590	WP_023464367.1	aldehyde dehydrogenase family protein	-
I5155_RS23175	4922531..4923007	+	477	WP_004353334.1	elongation factor GreAB	-
I5155_RS23180	4923010..4923285	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T170125 WP_003086331.1 NZ_CP060243:c4918945-4918190 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T170125 NZ_CP077086:2603648-2603929 [Pseudomonas zarinae]
ATGACCTATGAGTTGGAGTTTTCCGATAAGGCATGGAAGGAATGGCAAAAGCTGGGAGCAACACTCAAGGAGCAATTCAA
GAAAAAGCTTGAAGAGCGACTGGTAAATCCGCATGTCCAGGCAGACCGACTGCACGGATTGGGCAATGCCTATAAAATCA
AGTTGCGTAACGCCGGCTATCGATTGGTTTATCGGGTAGTAGATGATTTGCTGGTTGTCACGGTAATCGCAGTGGGTAAG
CGCGAGCGCGGCCAAGTGTATGACGAGGCTGCCAAGCGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT170125 WP_003086329.1 NZ_CP060243:c4919448-4919080 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT170125 NZ_CP077086:2603410-2603658 [Pseudomonas zarinae]
ATGACACATATCGTGCTTTCTCAGGTTGTAGCCAGTATTTCCGAGCTTAAGAAAAATCCGATGGGCACTGTCGCTGCCGG
GGGAGGGTTATCTGTAGCGATCCTCAACCGCAACGAGCCGGCTTTTTATTGCGTCCCTGCTAGGGAGTATGAAGCCATGA
TGGATCGGCTTGAAGACATGGAGTTGGTCGCTCTCTGCCGCGAGCGTGAAAATGATCCAACGATCAAGGTTTCTCTTGAT
GACCTATGA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7