Detailed information of TA system TA170124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3955129..3956350
• Replicon: chromosome
• Accession: NZ_CP060243
• Organism: Pseudomonas aeruginosa strain A-I-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: I5155_RS18580
• Protein ID: WP_003110488.1
• Coordinates: 3955772..3956350 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I5155_RS18575
• Protein ID: WP_003088112.1
• Coordinates: 3955129..3955683 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5155_RS18550	3950697..3951248	+	552	WP_003450159.1	XRE family transcriptional regulator	-
I5155_RS18555	3951245..3951643	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
I5155_RS18560	3951656..3951979	-	324	WP_015648646.1	multidrug efflux SMR transporter	-
I5155_RS18565	3952310..3952771	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
I5155_RS18570	3952776..3954971	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
I5155_RS18575	3955129..3955683	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
I5155_RS18580	3955772..3956350	+	579	WP_003110488.1	HD domain-containing protein	Toxin
I5155_RS18585	3956459..3957646	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
I5155_RS18590	3957636..3959807	-	2172	WP_025297367.1	type I secretion system permease/ATPase	-
I5155_RS18595	3959797..3961074	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T170124 WP_003110488.1 NZ_CP060243:3955772-3956350 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T170124 NZ_CP077085:2989183-2989764 [Pseudomonas shahriarae]
ATGGACATCGAAAAAATCAAAGGGCGCCTCGAATTTCTACGCGAGGCGGAAAAGCTCAAAGACGTGCTTAGAAGCGCGCA
CACCTCTTGCGGGCGCACCGAAAGCACGGCGGAGCATAGCTGGCGCCTTTGCCTGATGGCCATTGTCTTTGGGGACTACC
TGACTGATCTCGATCGGCTGAAAATGCTCAAGATGTGTGTTATCCACGACTTGGGGGAGGCCATTAACGGAGATGTTCCC
GCCGTCAATCAAGATTCGTTTCCCAACAAGAGCGAGCAAGAGAGAAACGATCTCCTGCTCTTGACCAGTGCCCTGGATGA
ACCGTTGAAGGCCGAGATACTGGCGCTTTGGGATGACTATGAAAATGCTTCGTCGCCAGAGGCCGTAGCCGTCAAGGCGC
TGGATAAGTTGGAAACGATGCTGCAGCACAACCAAGGCAAGAACCCAACGGGCTTCGATTACGAATTCAATCTTGCCTAT
GGCAAAAAATACACAGATGCCGCGCCGTTGTTTGAGGTGCTGCGCACTATCATCGACCAGGAGACCAAAGAACACATACT
GGCGAATTCTAAAAATCACTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT170124 WP_003088112.1 NZ_CP060243:3955129-3955683 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT170124 NZ_CP077085:2988518-2989075 [Pseudomonas shahriarae]
ATGTCTGACATGTTGCTAAGTCCTGTCTTACCCGGCGTTATGCTCAGGCGATGGCGCCTGTTACACCGGGTCAAACAATC
CCATGCCGCGGAGCTGTTTAACGTCACTCAATCGACTATCTCTCGCTGGGAGAGTGGCGTACTCGAGTTGGATCCTCTCG
CGCACAAAAAGCTTGAGCAATTGCTGGCCGCTCGTCTCACCACCGCGGCGGATAAAGCGCTGGGACGAATGGTGCGGGAA
AGCTCGCGTCCTGTTCATCTCATGTGTGATTTGACGCACCGTCTGCTTGCTTGTTCTCCTTCGCGCGCCGCCCAGTTCAC
GAGTCCGGTCAGTGAACTGCTGGGTCGCTCGCTATGGCGCTTCGCTACGCCCAATATCATCAGCACCGAGCTCGCCCTGG
ATAAATTGGGCTGGCGGGAAGCCTTTGCACCCCCCGCGCTGGAGTTTCTGACGGGTGACAATAATTCGTCCATCGTTCCG
ATCAGCCAAAGCCTGTGTCGTTGGACGCGTATGCCCCTGTGCGACGGAACAACAGCGCGCTTGGTCGAGTCGCTCTGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4