Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3955129..3956350 | Replicon | chromosome |
| Accession | NZ_CP060243 | ||
| Organism | Pseudomonas aeruginosa strain A-I-1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
| Locus tag | I5155_RS18580 | Protein ID | WP_003110488.1 |
| Coordinates | 3955772..3956350 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | I5155_RS18575 | Protein ID | WP_003088112.1 |
| Coordinates | 3955129..3955683 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I5155_RS18550 | 3950697..3951248 | + | 552 | WP_003450159.1 | XRE family transcriptional regulator | - |
| I5155_RS18555 | 3951245..3951643 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| I5155_RS18560 | 3951656..3951979 | - | 324 | WP_015648646.1 | multidrug efflux SMR transporter | - |
| I5155_RS18565 | 3952310..3952771 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| I5155_RS18570 | 3952776..3954971 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| I5155_RS18575 | 3955129..3955683 | + | 555 | WP_003088112.1 | helix-turn-helix domain-containing protein | Antitoxin |
| I5155_RS18580 | 3955772..3956350 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
| I5155_RS18585 | 3956459..3957646 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| I5155_RS18590 | 3957636..3959807 | - | 2172 | WP_025297367.1 | type I secretion system permease/ATPase | - |
| I5155_RS18595 | 3959797..3961074 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T170124 WP_003110488.1 NZ_CP060243:3955772-3956350 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
>T170124 NZ_CP077085:2989183-2989764 [Pseudomonas shahriarae]
ATGGACATCGAAAAAATCAAAGGGCGCCTCGAATTTCTACGCGAGGCGGAAAAGCTCAAAGACGTGCTTAGAAGCGCGCA
CACCTCTTGCGGGCGCACCGAAAGCACGGCGGAGCATAGCTGGCGCCTTTGCCTGATGGCCATTGTCTTTGGGGACTACC
TGACTGATCTCGATCGGCTGAAAATGCTCAAGATGTGTGTTATCCACGACTTGGGGGAGGCCATTAACGGAGATGTTCCC
GCCGTCAATCAAGATTCGTTTCCCAACAAGAGCGAGCAAGAGAGAAACGATCTCCTGCTCTTGACCAGTGCCCTGGATGA
ACCGTTGAAGGCCGAGATACTGGCGCTTTGGGATGACTATGAAAATGCTTCGTCGCCAGAGGCCGTAGCCGTCAAGGCGC
TGGATAAGTTGGAAACGATGCTGCAGCACAACCAAGGCAAGAACCCAACGGGCTTCGATTACGAATTCAATCTTGCCTAT
GGCAAAAAATACACAGATGCCGCGCCGTTGTTTGAGGTGCTGCGCACTATCATCGACCAGGAGACCAAAGAACACATACT
GGCGAATTCTAAAAATCACTAA
ATGGACATCGAAAAAATCAAAGGGCGCCTCGAATTTCTACGCGAGGCGGAAAAGCTCAAAGACGTGCTTAGAAGCGCGCA
CACCTCTTGCGGGCGCACCGAAAGCACGGCGGAGCATAGCTGGCGCCTTTGCCTGATGGCCATTGTCTTTGGGGACTACC
TGACTGATCTCGATCGGCTGAAAATGCTCAAGATGTGTGTTATCCACGACTTGGGGGAGGCCATTAACGGAGATGTTCCC
GCCGTCAATCAAGATTCGTTTCCCAACAAGAGCGAGCAAGAGAGAAACGATCTCCTGCTCTTGACCAGTGCCCTGGATGA
ACCGTTGAAGGCCGAGATACTGGCGCTTTGGGATGACTATGAAAATGCTTCGTCGCCAGAGGCCGTAGCCGTCAAGGCGC
TGGATAAGTTGGAAACGATGCTGCAGCACAACCAAGGCAAGAACCCAACGGGCTTCGATTACGAATTCAATCTTGCCTAT
GGCAAAAAATACACAGATGCCGCGCCGTTGTTTGAGGTGCTGCGCACTATCATCGACCAGGAGACCAAAGAACACATACT
GGCGAATTCTAAAAATCACTAA
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT170124 WP_003088112.1 NZ_CP060243:3955129-3955683 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
>AT170124 NZ_CP077085:2988518-2989075 [Pseudomonas shahriarae]
ATGTCTGACATGTTGCTAAGTCCTGTCTTACCCGGCGTTATGCTCAGGCGATGGCGCCTGTTACACCGGGTCAAACAATC
CCATGCCGCGGAGCTGTTTAACGTCACTCAATCGACTATCTCTCGCTGGGAGAGTGGCGTACTCGAGTTGGATCCTCTCG
CGCACAAAAAGCTTGAGCAATTGCTGGCCGCTCGTCTCACCACCGCGGCGGATAAAGCGCTGGGACGAATGGTGCGGGAA
AGCTCGCGTCCTGTTCATCTCATGTGTGATTTGACGCACCGTCTGCTTGCTTGTTCTCCTTCGCGCGCCGCCCAGTTCAC
GAGTCCGGTCAGTGAACTGCTGGGTCGCTCGCTATGGCGCTTCGCTACGCCCAATATCATCAGCACCGAGCTCGCCCTGG
ATAAATTGGGCTGGCGGGAAGCCTTTGCACCCCCCGCGCTGGAGTTTCTGACGGGTGACAATAATTCGTCCATCGTTCCG
ATCAGCCAAAGCCTGTGTCGTTGGACGCGTATGCCCCTGTGCGACGGAACAACAGCGCGCTTGGTCGAGTCGCTCTGA
ATGTCTGACATGTTGCTAAGTCCTGTCTTACCCGGCGTTATGCTCAGGCGATGGCGCCTGTTACACCGGGTCAAACAATC
CCATGCCGCGGAGCTGTTTAACGTCACTCAATCGACTATCTCTCGCTGGGAGAGTGGCGTACTCGAGTTGGATCCTCTCG
CGCACAAAAAGCTTGAGCAATTGCTGGCCGCTCGTCTCACCACCGCGGCGGATAAAGCGCTGGGACGAATGGTGCGGGAA
AGCTCGCGTCCTGTTCATCTCATGTGTGATTTGACGCACCGTCTGCTTGCTTGTTCTCCTTCGCGCGCCGCCCAGTTCAC
GAGTCCGGTCAGTGAACTGCTGGGTCGCTCGCTATGGCGCTTCGCTACGCCCAATATCATCAGCACCGAGCTCGCCCTGG
ATAAATTGGGCTGGCGGGAAGCCTTTGCACCCCCCGCGCTGGAGTTTCTGACGGGTGACAATAATTCGTCCATCGTTCCG
ATCAGCCAAAGCCTGTGTCGTTGGACGCGTATGCCCCTGTGCGACGGAACAACAGCGCGCTTGGTCGAGTCGCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|