Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2913316..2914358 | Replicon | chromosome |
| Accession | NZ_CP060243 | ||
| Organism | Pseudomonas aeruginosa strain A-I-1 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | I5155_RS13940 | Protein ID | WP_003153636.1 |
| Coordinates | 2913783..2914358 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | I5155_RS13935 | Protein ID | WP_003050245.1 |
| Coordinates | 2913316..2913786 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I5155_RS13900 | 2908708..2910126 | - | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
| I5155_RS13905 | 2910116..2911027 | - | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
| I5155_RS13910 | 2911024..2911716 | - | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
| I5155_RS13915 | 2911713..2912111 | - | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
| I5155_RS13920 | 2912123..2912482 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| I5155_RS13925 | 2912499..2912732 | - | 234 | WP_023101201.1 | TIGR03758 family integrating conjugative element protein | - |
| I5155_RS13930 | 2912729..2913112 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| I5155_RS13935 | 2913316..2913786 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| I5155_RS13940 | 2913783..2914358 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| I5155_RS13945 | 2914376..2915290 | + | 915 | WP_016852809.1 | AAA family ATPase | - |
| I5155_RS13950 | 2915287..2915757 | + | 471 | WP_003090160.1 | hypothetical protein | - |
| I5155_RS13955 | 2915754..2916254 | + | 501 | WP_003090159.1 | hypothetical protein | - |
| I5155_RS13960 | 2916254..2917156 | + | 903 | WP_003090158.1 | nucleotidyltransferase domain-containing protein | - |
| I5155_RS13965 | 2917195..2917920 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T170123 WP_003153636.1 NZ_CP060243:2913783-2914358 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T170123 NZ_CP077085:c2392236-2391985 [Pseudomonas shahriarae]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTTAACCTGCAGATGGCATTTACCTGGCCCGAGCTCGTGACATTGTT
AGGCTGGCTGGGTTACCGACAAATCGAAGGGGCTGGGAGCCGCGTCAAGTTCGACATAGGCGACCCGAGTGCAATGATCA
CCTTGCACAAGCCCCACCCTGGCAATGAACTGAAGTACTACATTCGGCGCCAGATCATTGAACAGTTGGAATCAGGAGGC
TTGATTCAGTGA
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTTAACCTGCAGATGGCATTTACCTGGCCCGAGCTCGTGACATTGTT
AGGCTGGCTGGGTTACCGACAAATCGAAGGGGCTGGGAGCCGCGTCAAGTTCGACATAGGCGACCCGAGTGCAATGATCA
CCTTGCACAAGCCCCACCCTGGCAATGAACTGAAGTACTACATTCGGCGCCAGATCATTGAACAGTTGGAATCAGGAGGC
TTGATTCAGTGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT170123 WP_003050245.1 NZ_CP060243:2913316-2913786 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT170123 NZ_CP077085:c2391988-2391623 [Pseudomonas shahriarae]
GTGAGCAACCAGTTGAAACACAAAGGTTACATCGGCTCCATAGAAGCCAGCGTCGAGGACAATTGCCTGTTCGGCAAGCT
GCTGTTTATCCGCCCCCTGGTCAGTTACGAAGGGCAGACCGTGGCCCAGTTGGAGGCCGCCTTTCGCGAGGCCGTGGAGG
ATTATCTGGTTACTTGCCAGACCCTGGGCCAGGCACCGGAAAAGCCCTGCAAAGGCTCCTTCAATGTACGGGTCGGCCAT
GATCTGCACCTGGCTGCGGCCCTGGCGGCGACGCAGAAAAAGGTCACGCTCAACGACCTGACACGCCAGGCGCTGAACGA
GTTCCTGCGCCATCACCGTACAGACAGCCACCCCGCCCTGGGGTGA
GTGAGCAACCAGTTGAAACACAAAGGTTACATCGGCTCCATAGAAGCCAGCGTCGAGGACAATTGCCTGTTCGGCAAGCT
GCTGTTTATCCGCCCCCTGGTCAGTTACGAAGGGCAGACCGTGGCCCAGTTGGAGGCCGCCTTTCGCGAGGCCGTGGAGG
ATTATCTGGTTACTTGCCAGACCCTGGGCCAGGCACCGGAAAAGCCCTGCAAAGGCTCCTTCAATGTACGGGTCGGCCAT
GATCTGCACCTGGCTGCGGCCCTGGCGGCGACGCAGAAAAAGGTCACGCTCAACGACCTGACACGCCAGGCGCTGAACGA
GTTCCTGCGCCATCACCGTACAGACAGCCACCCCGCCCTGGGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|