Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2085402..2086910 Replicon chromosome
Accession NZ_CP060243
Organism Pseudomonas aeruginosa strain A-I-1

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag I5155_RS09875 Protein ID WP_003119682.1
Coordinates 2085402..2085989 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A6V2F0
Locus tag I5155_RS09880 Protein ID WP_012074952.1
Coordinates 2086056..2086910 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5155_RS09870 2081657..2085136 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
I5155_RS09875 2085402..2085989 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
I5155_RS09880 2086056..2086910 + 855 WP_012074952.1 AraC family transcriptional regulator Antitoxin
I5155_RS09885 2087006..2089171 + 2166 WP_025297505.1 TonB-dependent receptor family protein -
I5155_RS09890 2089346..2091220 + 1875 WP_003117607.1 MFS transporter -
I5155_RS09895 2091281..2091490 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

DNA binding HTH domain, AraC-type

(196-273)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T170122 WP_003119682.1 NZ_CP060243:2085402-2085989 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T170122 NZ_CP077085:c2084551-2084366 [Pseudomonas shahriarae]
ATGAAATGTAATGAGTTCAAGCGGTGGCTGTTAGCTCAAGGGGTAGAGGTTTCCAAGACTGCAAAAGGAAGCCACTTCAA
AATCTACTTCAACGGCAAACAGACAACCCTTCCCAACCACGGGGCCAAGGAGATGGCCGAAGGGACTAGGAAGGCGATAA
TCAAACAACTGGGCCTCAAGGACTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31788.11 Da        Isoelectric Point: 7.7066

>AT170122 WP_012074952.1 NZ_CP060243:2086056-2086910 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSGFALVFIEQGAQRFRHRGGEHLAPWGSMVLINPDEVHTGSK
AHDSGWLYRGYYPEVEQIASILDELEIRHGGVPRFADSVVHDQPLARAFVHLHRLLADHAGSLETQTCWRETLLALFRRH
ARLPEAPKAGSEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKNGRA
PLDVALELGFADQSHLGRQFKQAYGVAPGEYRAACARSSLTMCE

Download         Length: 855 bp

>AT170122 NZ_CP077085:c2084316-2083894 [Pseudomonas shahriarae]
ATGTACGACTACGCAATCAGCGTGACTGAAGAGGCTGGCTCGTTCTGGTCATCGTGCGACGACATCCCAGAGGCACACAG
CGCTGGCGATACGCTCGAAGAGCTATTGACCCACGCCGCCGAAGGGCTTGAGGTCGCGCTCTCGATCTACGTCGATCAGT
TGCGGCACATCCCGAAGGCATCGCCACCAAAAGATGGCCAGCACGTTGTCCGGCTGTCCGCCCTGGTGGTGGCCAAGGTC
GAGCTATGGAATGCCATGCGCGACAAAGGAATGCGGAAAGCTGACTTGTGTCGGCTTCTCGGCGCTGCGCAAACAAAAGT
GGATCGCCTGGTGGACTTTGAGCACAGCTCGAAAATCGAGCAGGTTGAGTCAGCCTTGGCCGCCCTGGGCAAGCGCCTGG
TCGTATCTGTCGAGCCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A6V2F0

References