170120

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 184979..185484 Replicon chromosome
Accession NZ_CP060243
Organism Pseudomonas aeruginosa strain A-I-1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag I5155_RS00905 Protein ID WP_003083773.1
Coordinates 184979..185260 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag I5155_RS00910 Protein ID WP_003083775.1
Coordinates 185257..185484 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5155_RS00880 180230..181579 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
I5155_RS00885 181628..182314 + 687 WP_003083762.1 FadR family transcriptional regulator -
I5155_RS00890 182415..183149 + 735 WP_004346926.1 GntR family transcriptional regulator -
I5155_RS00895 183353..183739 + 387 WP_014602345.1 aegerolysin family protein -
I5155_RS00900 183771..184679 - 909 WP_003083769.1 LysR family transcriptional regulator -
I5155_RS00905 184979..185260 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
I5155_RS00910 185257..185484 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
I5155_RS00915 185660..186280 - 621 WP_003101226.1 hypothetical protein -
I5155_RS00920 186381..186881 + 501 WP_003101228.1 LEA type 2 family protein -
I5155_RS00925 186954..187295 + 342 WP_003101229.1 alkylphosphonate utilization protein -
I5155_RS00930 187377..188804 - 1428 WP_003083784.1 GABA permease -
I5155_RS00935 188973..190466 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T170120 WP_003083773.1 NZ_CP060243:c185260-184979 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T170120 NZ_CP077085:c1660899-1660717 [Pseudomonas shahriarae]
GTGGATAGCCGATATTTGATAGGCCATATCGTGGCTGATGGCTGGTACCTGGTGCGCGTCAGGGGCAGTCATCATCATTT
TAAACACCCTGCCAAGCCTGGGCTGGTGACCATTCCCCACCCCAAGAAGCATCTGTTGGACAAGACCGCCAAGAGCATCT
TGAAACAAGCTCTGCTCGCTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT170120 WP_003083775.1 NZ_CP060243:c185484-185257 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT170120 NZ_CP077085:c1660694-1660284 [Pseudomonas shahriarae]
ATGCTGTATCCGATTGCAATTTCAACCGGCGACGATGACCACGCCTGGGGCGTAGAAGTCCCCGACATCCCTGGCTGCTT
CTCTGCCGGTGATGACCTGGACGACGCCATGGCCATGGCACGGGAAGCCATAGAAGGCCATTTTGAGCTGCTGGCCGAAG
AGGGCGCGCCCATTCCCAGCGCACAAAAGGTCACGCTGCACGCAGCCAACCCCCTGTACGCCGGCTGTACCTGGGCGGTG
GTGGATATTGATGTGACCAAGTACCTGGGCAAGGCGCAAAAACTCAACATCACGCTGCCTGGCTACTTGCTCAACCGCAT
TGATGAGTACGTGCTGCACCACCCGGAAGAAAAAAGTCGTTCGGGGTTCCTGGCATCGGCAGCGCTGAAGGTGCTGCAAC
AGGAGCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References