170119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6485120..6485625 Replicon chromosome
Accession NZ_CP060242
Organism Pseudomonas aeruginosa strain B-I-1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag I5154_RS30345 Protein ID WP_003083773.1
Coordinates 6485120..6485401 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag I5154_RS30350 Protein ID WP_003083775.1
Coordinates 6485398..6485625 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5154_RS30320 6480371..6481720 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
I5154_RS30325 6481769..6482455 + 687 WP_003083762.1 FadR family transcriptional regulator -
I5154_RS30330 6482556..6483290 + 735 WP_003083764.1 GntR family transcriptional regulator -
I5154_RS30335 6483494..6483880 + 387 WP_003083767.1 aegerolysin family protein -
I5154_RS30340 6483912..6484820 - 909 WP_003083769.1 LysR family transcriptional regulator -
I5154_RS30345 6485120..6485401 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
I5154_RS30350 6485398..6485625 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
I5154_RS30355 6485801..6486421 - 621 WP_003101226.1 hypothetical protein -
I5154_RS30360 6486522..6487022 + 501 WP_003083778.1 LEA type 2 family protein -
I5154_RS30365 6487095..6487436 + 342 WP_014603467.1 alkylphosphonate utilization protein -
I5154_RS30370 6487518..6488945 - 1428 WP_003083784.1 GABA permease -
I5154_RS30375 6489114..6490607 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T170119 WP_003083773.1 NZ_CP060242:c6485401-6485120 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T170119 NZ_CP077085:117501-118379 [Pseudomonas shahriarae]
ATGTTGCCAGGACTCACGCACGCCGCGCCGACGGCCGACCTGCAAGCCCAACTGCAGCGCGATTTCCCCCAGCAACGGGT
CGCGTCAGCAGGAGGCCAGCAGGCCCTGCGGGTATGCGGCACGGGACCGGCAGTGGTGTTGCTGCACGGCATAGGCTCCG
GCGCGGCGTCCTGGCTGCAGGTGGCACAACATCTGGCGGCCCAGGCGCGGGTCATCGCCTGGGACGCGCCCGGCTATGGC
GACTCCAGCCCCCTGGAATCGCAAGTACCCAAGGCCGAGCAATACGCCGCGCGCCTGGTGCAGATGCTCGATGCGCTGGA
GGTGGACGAGTGCGCGCTGGTCGGCCATTCCCTGGGCGCACTGACCGCCCTGGCCTTGGCCCGCAGTGCCCAGGCCAGAC
GCGTGAGCCGCCTGGTACTGATCAGCCCCGCTCGTGGCTATGGCGCGCCCGAGCGCAACGCGCAGCGCCAGCAAGTGCGC
CAGCAACGCCTGGACAACCTGCAACGCCTGGGCATCGCCGGGCTGGCCGAGCAGCGCAGCGCCCACATGCTCTCGCCCAG
TGCCCAGCCCCAAGCGTTGGCCTGGGTGCACTGGAACATGGCCCGCCTGAACCCGCTGGGCTATCGCCAGGCCATCGAAT
TGCTGTGCGGCGACGACTTGCTGCGCCACGGCCAACCTGCAATGCCCTGCGAGGTGCATTGCGGCGAAGCCGACAGCATC
ACCCCACCCGACACCTGCCTGGGCGTGGCCAAGGCCCTGGGTGCCAGCTTCAACCTGATCGCCGACGCAGGCCATGCCAG
CCCCATCGAACAACCGCTGGTGGTTGCCGGTCGCCTGGCCTACGCCCTCAAACAATCCCTGACAGGTAGAACCCTATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT170119 WP_003083775.1 NZ_CP060242:c6485625-6485398 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT170119 NZ_CP077085:118376-119209 [Pseudomonas shahriarae]
ATGAACGACTCAGATCTGCTGAAGGATGCTCAGGACAAATACATCGTGCCGGGCCTGGAGCGCGGCTTGTTGCTGCTCTG
CGAGTTCAGCCGGCGCAACCGGACCCTGACCGCGCCGGAACTGGCGCGGCGCCTGGCGCTGCCGCGCTCGACGATTTTCC
GCTTGCTGACCACCCTGGAAACCATGGGCTTCGTCACCCGCAGCGGCAACGAGTACCGCCTGGGCATGTCGGTGCTGCGC
CTGGGCTTCGAGTATCTGGCGTCGCTGGAGCTGACCGAACTCGGCCAGCCACTGCTGGCGCGTTTGTGCGACCGGGTTAA
CTACCCGAGCAACCTGGTGGTGCGCGACGGGCGTTCCATCGTGTACGTGGCCAAGGTGTCGCCGCCTTCGGTGTTCTCCA
ACGCGGTCAACGTCGGCACCCGCCTGCCGGCCCATGCCACGGTGCTGGGGCGCATTCTCCTCGAAGACCTGTCACTGGCC
GAACTGCGCGAGCTGTACCCCGAGGAGCACTTGGAACAGCACTCCCACTGCACCCCGAAAACCGTGATGGAGCTGTTCGA
CATGCTCCAGGCCGACCGCCAGCGCGGCTTTGTCAGCGGCGAAGGGTTCTTTGAATCGGCGATTTCCACAGTGGCCGCGC
CCGTGCGCGACCAGAGCGGCGACATCGTGGCCGCCCTCGGCGTGACCATCCCGACCACGCAGATCGGTCATGTGAATTTT
GAAGAGCTGCTGAACCAAGTGCGGCGCAGCGCCGACGAGCTGTCGCGCCTGCTCAACTACAACGGCGGCGCCCACAGCGG
GCAGCCCCGCGTCACTGCCTTGATGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References