Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2861494..2862536 | Replicon | chromosome |
| Accession | NZ_CP060242 | ||
| Organism | Pseudomonas aeruginosa strain B-I-1 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | I5154_RS13465 | Protein ID | WP_003153636.1 |
| Coordinates | 2861961..2862536 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | I5154_RS13460 | Protein ID | WP_003050245.1 |
| Coordinates | 2861494..2861964 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I5154_RS13425 | 2856886..2858304 | - | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
| I5154_RS13430 | 2858294..2859205 | - | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
| I5154_RS13435 | 2859202..2859894 | - | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
| I5154_RS13440 | 2859891..2860289 | - | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
| I5154_RS13445 | 2860301..2860660 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| I5154_RS13450 | 2860677..2860910 | - | 234 | WP_003090170.1 | TIGR03758 family integrating conjugative element protein | - |
| I5154_RS13455 | 2860907..2861290 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| I5154_RS13460 | 2861494..2861964 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| I5154_RS13465 | 2861961..2862536 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| I5154_RS13470 | 2862554..2863468 | + | 915 | WP_016852809.1 | AAA family ATPase | - |
| I5154_RS13475 | 2863465..2863935 | + | 471 | WP_003090160.1 | hypothetical protein | - |
| I5154_RS13480 | 2863932..2864432 | + | 501 | WP_003090159.1 | hypothetical protein | - |
| I5154_RS13485 | 2864432..2865334 | + | 903 | WP_003090158.1 | nucleotidyltransferase domain-containing protein | - |
| I5154_RS13490 | 2865373..2866098 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2786929..2908517 | 121588 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T170116 WP_003153636.1 NZ_CP060242:2861961-2862536 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T170116 NZ_CP077084:3897402-3897716 [Pseudomonas tritici]
ATGATTTTCATTGAAACTGCGGTTTTCACCCGGCGTGTAACGGAGCTCATGAATCACGACGCCTACCTGGGTTTGCAGGT
AGCGTTGATGTTCAATCCGTGCGTTGGAGATGTGATCGAAGGAACGGGCGGCATCCGAAAGCTGCGTATTGCTTCAAAAG
GTCACGGCAAACGAGGCGGCGCCAGAGTGATTTACTACCACTTTGTAACGGCTTCAAAAATTGCGTTATTAATGATCTAT
CCAAAAAACGAACAGCAAGACCTGACTAACGATGAACGCAAAGCACTGAAAGCCGTCATCGAACACTGGAGATAA
ATGATTTTCATTGAAACTGCGGTTTTCACCCGGCGTGTAACGGAGCTCATGAATCACGACGCCTACCTGGGTTTGCAGGT
AGCGTTGATGTTCAATCCGTGCGTTGGAGATGTGATCGAAGGAACGGGCGGCATCCGAAAGCTGCGTATTGCTTCAAAAG
GTCACGGCAAACGAGGCGGCGCCAGAGTGATTTACTACCACTTTGTAACGGCTTCAAAAATTGCGTTATTAATGATCTAT
CCAAAAAACGAACAGCAAGACCTGACTAACGATGAACGCAAAGCACTGAAAGCCGTCATCGAACACTGGAGATAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT170116 WP_003050245.1 NZ_CP060242:2861494-2861964 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT170116 NZ_CP077084:3897719-3898006 [Pseudomonas tritici]
ATGAGCAAATTCTTCGATGAGCTGATGGAAAGCGTGCAACAGATGGACGAAATCGTCCGAGGCGAGCGCAAGCCCTCTCG
CGAATTCATTGTTGACGCGCTTCAAGTCAAACAAATCCGTAAGGCAACGGGCCTGACTCAAGCCAAATTCGCAGCCATCA
TCGATGTTCAAATCGGCACGCTACGTAATTGGGAACAGGGGCGACGCGAACCAACAGGGCCAGCAAAGGCGCTGTTGAGG
GCCATTCACAATGACCCGGTCCATGTGTTGAATGCGTTGGCCCTTTAA
ATGAGCAAATTCTTCGATGAGCTGATGGAAAGCGTGCAACAGATGGACGAAATCGTCCGAGGCGAGCGCAAGCCCTCTCG
CGAATTCATTGTTGACGCGCTTCAAGTCAAACAAATCCGTAAGGCAACGGGCCTGACTCAAGCCAAATTCGCAGCCATCA
TCGATGTTCAAATCGGCACGCTACGTAATTGGGAACAGGGGCGACGCGAACCAACAGGGCCAGCAAAGGCGCTGTTGAGG
GCCATTCACAATGACCCGGTCCATGTGTTGAATGCGTTGGCCCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|