Detailed information of TA system TA170113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 6161451..6161956
• Replicon: chromosome
• Accession: NZ_CP060241
• Organism: Pseudomonas aeruginosa strain C-I-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: I6A80_RS28450
• Protein ID: WP_003083773.1
• Coordinates: 6161675..6161956 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: I6A80_RS28445
• Protein ID: WP_003083775.1
• Coordinates: 6161451..6161678 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6A80_RS28420	6156469..6157962	+	1494	WP_196426311.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
I6A80_RS28425	6158131..6159558	+	1428	WP_003083784.1	GABA permease	-
I6A80_RS28430	6159640..6159981	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
I6A80_RS28435	6160054..6160554	-	501	WP_003112629.1	LEA type 2 family protein	-
I6A80_RS28440	6160655..6161275	+	621	WP_003101226.1	hypothetical protein	-
I6A80_RS28445	6161451..6161678	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
I6A80_RS28450	6161675..6161956	+	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
I6A80_RS28455	6162256..6163164	+	909	WP_003083769.1	LysR family transcriptional regulator	-
I6A80_RS28460	6163196..6163582	-	387	WP_014602345.1	aegerolysin family protein	-
I6A80_RS28465	6163786..6164520	-	735	WP_003117208.1	GntR family transcriptional regulator	-
I6A80_RS28470	6164621..6165307	-	687	WP_003083762.1	FadR family transcriptional regulator	-
I6A80_RS28475	6165356..6166705	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T170113 WP_003083773.1 NZ_CP060241:6161675-6161956 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T170113 NZ_CP077084:c1834167-1833985 [Pseudomonas tritici]
GTGGATAGCCGATATTTAATAGGTCACATCGTTGCGGACGGTTGGTATCTGGTGCGCATCAAAGGCAGTCATCACCACTT
CAAACACCCGACAAAACCGGGGCTGGTGACGATTCCACATCCAAAGAAGGACCTGTTGGACAAGACCGCCAAGAGCATTT
TGAAACAAGCTCTGTTGAGTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT170113 WP_003083775.1 NZ_CP060241:6161451-6161678 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT170113 NZ_CP077084:c1833962-1833552 [Pseudomonas tritici]
ATGCTTTACCCGATTGCAATTTCAACCGGCGACGACGATCACGCCTGGGGTGTAGAAGTGCCGGATATTCCCGGCTGCTA
TTCCGCCGGCGACGATTTGGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCGGAAG
ACGGTGCAGCGATTCCCAGTGCGCAAAAGGTCACCTTGCATGCCGCCAATCCTCAGTATGCAGGCTGCACCTGGGCAGTC
GTGGACATTGATGTCACCAAGTACCTGGGCAAAGCGCAGAAGCTCAATATCACGCTGCCCGGTTATCTGCTGAACCGCAT
CGATGAATATGTGCTGCATCACCCTGAAGAAAAAAGCCGTTCGGGGTTTCTGGCCTCAGCAGCGCTGAAAGTGCTTCAGC
AGGGGCATTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9