Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4499273..4500781 Replicon chromosome
Accession NZ_CP060241
Organism Pseudomonas aeruginosa strain C-I-1

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag I6A80_RS20690 Protein ID WP_003119682.1
Coordinates 4500194..4500781 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag I6A80_RS20685 Protein ID WP_003119683.1
Coordinates 4499273..4500127 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6A80_RS20670 4494692..4494901 + 210 WP_003115568.1 cold-shock protein -
I6A80_RS20675 4494962..4496836 - 1875 WP_003117607.1 MFS transporter -
I6A80_RS20680 4497011..4499176 - 2166 WP_058876957.1 TonB-dependent receptor family protein -
I6A80_RS20685 4499273..4500127 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
I6A80_RS20690 4500194..4500781 - 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
I6A80_RS20695 4501047..4504526 + 3480 WP_058876958.1 hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T170112 WP_003119682.1 NZ_CP060241:c4500781-4500194 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T170112 NZ_CP077083:c5171992-5171699 [Pseudomonas salmasensis]
ATGACCTATAGCCTTGATTTTGATGCGCGTGCATTGAAGGAATGGCAAAAGCTCGGTGACACCCTCCGTCAGCAACTCAA
AAAGAAGCTGGTCGAAATCCTGAACAACCCACGTATTGAAGCTAATCGCCTACATCGCCTGCCTGACTGCTACAAGATCA
AACTGCGTAGCAGCGGGTACAGGCTGGTGTATCAAGTGATCGAGCAGGAAATTACGGTGTTCGTGGTCGCCGTCGATAAA
CGTGAGCGTGATCAGGCTTATCGCAAAGCGTCTGAGCGCCTTGAACAGCGCTAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT170112 WP_003119683.1 NZ_CP060241:c4500127-4499273 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT170112 NZ_CP077083:c5172221-5171982 [Pseudomonas salmasensis]
TTGGCATCTATCAACATCCGTATCGATGACGACCTGAAAACTCGCGCCTACCTGGAGCTGGAGAAACTCGGTGTCACCCC
TTCCGAATTGATACGCCAGGCGTTGCAATATGTTGCCGAGCGCGGCCAGCTGCCATTTAAGCCTGTGCTGATGACTGAAG
AGGATGAAGCCTTGATGGCGACGGTACGTGAGCGCCTTGCGTCGCCTCAACGCGTGAGGGTTTCTTTGGATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References