Detailed information of TA system TA170111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2802572..2803793
• Replicon: chromosome
• Accession: NZ_CP060241
• Organism: Pseudomonas aeruginosa strain C-I-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: I6A80_RS13010
• Protein ID: WP_003102740.1
• Coordinates: 2802572..2803150 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I6A80_RS13015
• Protein ID: WP_003088112.1
• Coordinates: 2803239..2803793 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6A80_RS12995	2797848..2799125	+	1278	WP_003102743.1	TolC family protein	-
I6A80_RS13000	2799115..2801286	+	2172	WP_034011389.1	type I secretion system permease/ATPase	-
I6A80_RS13005	2801276..2802463	+	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
I6A80_RS13010	2802572..2803150	-	579	WP_003102740.1	HD domain-containing protein	Toxin
I6A80_RS13015	2803239..2803793	-	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
I6A80_RS13020	2803951..2806146	-	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
I6A80_RS13025	2806151..2806612	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
I6A80_RS13030	2806943..2807266	+	324	WP_003162861.1	multidrug efflux SMR transporter	-
I6A80_RS13035	2807279..2807677	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
I6A80_RS13040	2807674..2808225	-	552	WP_003450159.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T170111 WP_003102740.1 NZ_CP060241:c2803150-2802572 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T170111 NZ_CP077083:c5142085-5141903 [Pseudomonas salmasensis]
GTGGATAGCCGGTATTTGATAGGACACATCGTTGCAGACGGTTGGTATCTGGTGCGCATCAGGGGCAGTCATCATCACTT
CAAGCACCCGACAAAGCCGGGGCTCGTGACGATCCCACACCCCAAAAAGGACCTGCTGGATAAAACCGCCAAGAGCATTT
TGAAACAGGCTCTGCTGAGCTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT170111 WP_003088112.1 NZ_CP060241:c2803793-2803239 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT170111 NZ_CP077083:c5141881-5141471 [Pseudomonas salmasensis]
ATGCTTTACCCCATCGCAATTTCAACGGGCGACGCGGACCACGCCTGGGGCGTGGAAGTCCCGGATATTCCTGGCTGTTA
TTCGGCCGGCGAGGACCTGGATGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATCCTGGCAGAAG
ATGGCGCGCCGATCCCCACCGCGCAGAAAGTTACCGTACACGCTGCCAACCCTCAGTACGCCGGTTGCACATGGGCTGTG
GTGGACATCGACGTCACCAAATACCTGGGCAAAGCCCAAAAGCTCAACATCACCCTGCCCGGCTATCTGTTGAATCGCAT
CGATGAATACGTGCTGAATCATCCGCAGGAAAAGAGCCGTTCGGGGTTTCTGGCGTCGGCAGCGCTCAAGGTATTACAGC
AGGAGCGGTAG

Structures

Toxin

• AlphaFold DB: A0A0C7CS07