Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1867449..1868707 Replicon chromosome
Accession NZ_CP060241
Organism Pseudomonas aeruginosa strain C-I-1

Toxin (Protein)


Gene name - Uniprot ID A0A0H2Z7F3
Locus tag I6A80_RS08650 Protein ID WP_003140635.1
Coordinates 1867952..1868707 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag I6A80_RS08645 Protein ID WP_003086329.1
Coordinates 1867449..1867817 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6A80_RS08625 1863612..1863887 + 276 WP_172655204.1 zinc ribbon domain-containing protein -
I6A80_RS08630 1863890..1864366 - 477 WP_029611026.1 hypothetical protein -
I6A80_RS08635 1864445..1866034 + 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
I6A80_RS08640 1866090..1867376 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
I6A80_RS08645 1867449..1867817 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
I6A80_RS08650 1867952..1868707 + 756 WP_003140635.1 RES family NAD+ phosphorylase Toxin
I6A80_RS08655 1869477..1870838 + 1362 WP_003081943.1 DNA recombination protein RmuC -
I6A80_RS08660 1870993..1873536 - 2544 WP_079753647.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28220.34 Da        Isoelectric Point: 7.7294

>T170110 WP_003140635.1 NZ_CP060241:1867952-1868707 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T170110 NZ_CP077083:c5138290-5138006 [Pseudomonas salmasensis]
ATGCAGGTTGAGTGGCTGAGGGCAGCCCTCAGAAACCTTGACGATGAAGCGGCTTATATTGCCGAAGAAAACCCCAAAGC
AGCCCATGAATTTGTCCAGGCAATTCTAAGTGGTCTGGAACAGGTCGCCGCGTTTCCCGCGATGGGGAAAGAGGGACGAG
TGCCGGGGACTCGCGAGTGGGTTGTATCCCGATGGCCCTACATTGTTCCTTACCGAATTCGAGAGGGGCGACTACAAGTA
ATGCGGATTTTTCATACACGTCGTCAACCTCCGAAAGTCTGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT170110 WP_003086329.1 NZ_CP060241:1867449-1867817 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT170110 NZ_CP077083:c5138519-5138280 [Pseudomonas salmasensis]
ATGTCTGTTATGTCCCTACGTATACCGGAAGACGTCGCCGATACCCTCGCCAGTCTCGCCAAGGCTACCGGTCGCAGCAA
ATCCTTTCTGGCCGTTGACGCATTACGCGAATACCTGGCCCGCGAAGCCTGGCAAATCGAAGAAATCCAAAAAGCCGTGA
AAGAAGCGGATGCGGGGGATTTCGCCACGGCTGACGAGGTAAAGGCTGTCGCTGATAAATGGCGCGCCAATGCAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z7F3

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References