170106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4683915..4684555 Replicon chromosome
Accession NZ_CP060240
Organism Pseudomonas aeruginosa strain G-I-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I5102_RS21930 Protein ID WP_003134109.1
Coordinates 4683915..4684325 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I5102_RS21935 Protein ID WP_031634724.1
Coordinates 4684325..4684555 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5102_RS21890 4680042..4680239 + 198 WP_003105756.1 hypothetical protein -
I5102_RS21895 4680395..4681123 + 729 WP_003105754.1 TIGR03761 family integrating conjugative element protein -
I5102_RS21900 4681129..4681677 + 549 WP_003105753.1 DUF3158 family protein -
I5102_RS21905 4681724..4682563 + 840 WP_003105750.1 Rha family transcriptional regulator -
I5102_RS21910 4682593..4683081 + 489 WP_004352840.1 single-stranded DNA-binding protein -
I5102_RS21915 4683237..4683404 + 168 WP_128729268.1 CrpP family protein -
I5102_RS21920 4683470..4683688 - 219 WP_023083218.1 hypothetical protein -
I5102_RS21925 4683702..4683899 - 198 WP_023083219.1 hypothetical protein -
I5102_RS21930 4683915..4684325 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
I5102_RS21935 4684325..4684555 - 231 WP_031634724.1 antitoxin Antitoxin
I5102_RS21940 4684811..4686730 + 1920 WP_004352838.1 type I DNA topoisomerase -
I5102_RS21945 4687038..4687247 + 210 WP_003105733.1 cold-shock protein -
I5102_RS21950 4687468..4689357 + 1890 WP_031641300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4664629..4765716 101087


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T170106 WP_003134109.1 NZ_CP060240:c4684325-4683915 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T170106 NZ_CP077083:1191737-1192306 [Pseudomonas salmasensis]
ATGAACATCGACAAAATCAAAGGGCGCCTCGAATTCCTGCGAGAAACGGAAAAACTCAAGGATGTTCTCAGAAGTGCACA
CACCTCTTCCGGGCGCACCGAAAGCACGGCAGAACACAGTTGGCGTCTTTGTCTGATGGCTATTGTTTTCGAGGATCAAC
TGGCCGAACTCGACATGCTGAAGATTCTCAAGATGTGCGTCATTCACGATTTGGGTGAGGCCATCAATGGAGACATCCCG
GCCGTCAGCCAGGCAGCGTTTCCCAACAAGGGCGAGCAAGAGAGAGACGATCTTGTGCTTCTGACCTCTGCCCTGGATGA
GCCGCTGAAAGCTGAGATATTGGCGCTCTGGGATGACTATGAGCACGCACAGTCTGCGGAGGCAAAAGCCGTCAAGGCGC
TGGACAAGCTGGAAACGCTGCTCCAGCACAATCAGGGCAAGAACCCACCGGGCTTCAATTACGAGTTCAATCTGGCTTAC
GGTAAGAAGTACACAGATGCCGACCCTCTGTTTGAGCAACTTCGACATCTTATCGATGAGGACACTCGGGAAAAAATTTC
AAAGCAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT170106 WP_031634724.1 NZ_CP060240:c4684555-4684325 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT170106 NZ_CP077083:1191079-1191636 [Pseudomonas salmasensis]
ATGCCTGGCATCTTCCCAAAGCCAGCCTTGCCTGGCATCGCGCTCAGGCGGTGGCGCTTGTTGCACCGAGTCAAACAAGC
CCACGCTGCGCAGTTGTTCAACGTCACCCAATCCACTATTTCGCGCTGGGAAAGCGGCGTACAGGCAATCGACCCCTGCG
CGCACCAACAGCTTGAGCAATTACTCGCCGCCCGCCTTGATGCCGCCGCCGATCAAGCCTTGGCTCGCTTGGTCAGGGAA
AGCTCACGGCCCGTTCATCTCATGTGCGACCTGACCCATCGTCTGCTGGCTTGCTCCCCTGCCCGCGCAGCCCAGTTCGC
AAGCCCCGTCAGCGAATTGCTGGGGCGTTCGCTATGGCGCTTTGCGACACCGGAGATCATCAGCAAAGAACTCTCCCTGG
ATGAAACCGGGTGGAGGGAAGTCAGTGCGCCACCGACGATCGAATTCGTCACCGGCCACAATGACTCGCTTGTTGTGCCT
ATCAGCCAGAGCGCCTGTCGGTGGACGCGCATCCCTCTTTCAGACGGTACATCGGCGCGTTTGGTGGAGACGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References