Detailed information of TA system TA170105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4606815..4608073
• Replicon: chromosome
• Accession: NZ_CP060240
• Organism: Pseudomonas aeruginosa strain G-I-1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: I5102_RS21485
• Protein ID: WP_023084953.1
• Coordinates: 4606815..4607570 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: I5102_RS21490
• Protein ID: WP_003086329.1
• Coordinates: 4607705..4608073 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5102_RS21475	4601989..4604532	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
I5102_RS21480	4604687..4606048	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
I5102_RS21485	4606815..4607570	-	756	WP_023084953.1	RES family NAD+ phosphorylase	Toxin
I5102_RS21490	4607705..4608073	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
I5102_RS21495	4608146..4609432	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
I5102_RS21500	4609488..4611077	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
I5102_RS21505	4611156..4611632	+	477	WP_023122241.1	hypothetical protein	-
I5102_RS21510	4611635..4611910	-	276	WP_171945305.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28310.49 Da
• Isoelectric Point: 7.7294

>T170105 WP_023084953.1 NZ_CP060240:c4607570-4606815 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T170105 NZ_CP077083:944401-944652 [Pseudomonas salmasensis]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAATGAGCACATGGCATTTACCTGGTCTGAGCTCGTCACGTTATT
CCGCCGATTGGGATACACACAGATTGAAGGGGCTGGAAGCCGGGTCAAGTTCGACATGGGCGACCCCAGTGCAATGATCA
CCCTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT170105 WP_003086329.1 NZ_CP060240:c4608073-4607705 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT170105 NZ_CP077083:944649-945011 [Pseudomonas salmasensis]
ATGAATAACCAACTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
CCTCTTCATCAAGGCGCTGGTGAGCTACGAAGGCAAGACCGTCGCAGAGTTGGACGCCGCGTTCAAAGAGGCGGTGGAGG
ATTACCTCGCAACGTGCCAGGCCCTGGGACAGACACCCGAAAAACCCTGCAAGGGCTCCTTCAACGTGCGTGTCGGCCAC
GACCTGCACCTGGCTGCCGCCCTGGCGGCGACTCGAAAAAAAGTGACGTTGAACGACCTCACGCGCCAGGCGCTCAACGA
GTTCCTGCTGCAACATGGCGCAGAGGGGCTTGCCGCCGTTTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7