170104

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3689614..3690835 Replicon chromosome
Accession NZ_CP060240
Organism Pseudomonas aeruginosa strain G-I-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I5102_RS17185 Protein ID WP_003114949.1
Coordinates 3690257..3690835 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I5102_RS17180 Protein ID WP_003088112.1
Coordinates 3689614..3690168 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5102_RS17155 3685182..3685733 + 552 WP_003102727.1 XRE family transcriptional regulator -
I5102_RS17160 3685730..3686128 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
I5102_RS17165 3686141..3686464 - 324 WP_003102734.1 multidrug efflux SMR transporter -
I5102_RS17170 3686795..3687256 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
I5102_RS17175 3687261..3689456 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
I5102_RS17180 3689614..3690168 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
I5102_RS17185 3690257..3690835 + 579 WP_003114949.1 HD domain-containing protein Toxin
I5102_RS17190 3690943..3692130 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
I5102_RS17195 3692120..3694291 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
I5102_RS17200 3694281..3695558 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T170104 WP_003114949.1 NZ_CP060240:3690257-3690835 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T170104 NZ_CP077082:c6183820-6183629 [Pseudomonas sp. OE 28.3]
ATGAGAAGCAGAGAGGTGATCGAGCTTTTGGTTGAGGATGGATGGTTTGAGGTGGCGGTAAAGGGCAGCCATCACCAGTT
CAAACACCCTGAGAAGCGAGGACGTGTAACCGTGCCTCATCCCAAGTCAGAGATTGCCAAGGGCACCTTGCACAGTATTT
TTAAATCAGCAGGCCTCAACTGTAGAGCTTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT170104 WP_003088112.1 NZ_CP060240:3689614-3690168 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT170104 NZ_CP077082:c6183582-6183181 [Pseudomonas sp. OE 28.3]
ATGAAATTCCCAGTGGTAGTACACAAAGACGCCGACTCGGACTACAGCGTGACCGTTCCGGACGTACCAGGCTGCTTCTC
GGCAGGCGCTTCGTTTTCCGAGGCGTTGGATAATGTTCGGGAAGCGCTGGCGCTGCATCTCGAAGGGTTGGTCGCCGACG
AAGAAAAGCTTCCTCAGGCCCAAGAGGTGGATGTTCATCTGGACAATCCGGATTACGCCGGTGGCGTATGGGCGATTGTC
GACTTTGACCTGACTCCGTACTTGGGTAAGTCGGTGCGGTTCAACGCTTCTTTGCCGGAGCAGTTGTTGCACCGCATTGA
TGAGCGAGTGCAGAAGGATCATCGCTATGCATCGCGGTCAGGGTTTTTGGCGACGGCAGCGCTGCGTGAACTGGCCGTTT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References