Detailed information of TA system TA170102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 260847..261352
• Replicon: chromosome
• Accession: NZ_CP060240
• Organism: Pseudomonas aeruginosa strain G-I-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: I5102_RS01215
• Protein ID: WP_003083773.1
• Coordinates: 260847..261128 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: I5102_RS01220
• Protein ID: WP_003083775.1
• Coordinates: 261125..261352 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5102_RS01190	256098..257447	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
I5102_RS01195	257496..258182	+	687	WP_003083762.1	FadR family transcriptional regulator	-
I5102_RS01200	258283..259017	+	735	WP_023119575.1	GntR family transcriptional regulator	-
I5102_RS01205	259221..259607	+	387	WP_014602345.1	aegerolysin family protein	-
I5102_RS01210	259639..260547	-	909	WP_016561475.1	LysR family transcriptional regulator	-
I5102_RS01215	260847..261128	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
I5102_RS01220	261125..261352	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
I5102_RS01225	261528..262148	-	621	WP_003101226.1	hypothetical protein	-
I5102_RS01230	262249..262749	+	501	WP_003112629.1	LEA type 2 family protein	-
I5102_RS01235	262822..263163	+	342	WP_116829600.1	alkylphosphonate utilization protein	-
I5102_RS01240	263245..264672	-	1428	WP_003083784.1	GABA permease	-
I5102_RS01245	264841..266334	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T170102 WP_003083773.1 NZ_CP060240:c261128-260847 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T170102 NZ_CP077082:c5252316-5251918 [Pseudomonas sp. OE 28.3]
ATGCTCAAGTTCATGCTAGATACCAACATTTGCATCTTCACCATCAAAAACAAACCCCAACAGGTGCGTGAAACCTTCAA
AAGGCACCATGGCCAACTGGGTATTAGTACAGTGACCCTGATGGAGTTGATTTACGTTGCTGAAAAATCAGCTAACCCGG
AGCGAAACCTCGCCGACGTAGAAGGGTTTGCTGCGCGCCTGGAGGTTTTAAAATACGACCAAGACGCCGCGATACATACT
GGGCAGCTTCGCGCAGAGCTGGCTAGAGCGGGTACTCCGATAGGTCCCTATGACCAGATGATCGCCGGGCATGCCCGTTC
GCAGGGTCTGATTTTGGTCACGAATAATCGACGCGAGTTCGACCGCGTGCCAGGATTGCGGGTAGAAGATTGGGTGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT170102 WP_003083775.1 NZ_CP060240:c261352-261125 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT170102 NZ_CP077082:c5252546-5252316 [Pseudomonas sp. OE 28.3]
ATGGACCAAGGTTCTGTATTCCAAAGCAACCGCAGCCAAGCGGTACGTTTGCCAAAAGCTGCTGCCATGCCGGACGATGT
AAAGCGCGTAGATGTTATCTCTATCGGAAGAGCCAGAATCATCACCCCAGCCGGTGAGTCATGGGACAGCTGGTTTGATG
GCGAGGGGGTCACGCCTGACTTCATGACCGACCGCGAGCAACCAGCGGAACAAGAGCGGGAATCTTTTTAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9