Detailed information of TA system TA170098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2954817..2955430
• Replicon: chromosome
• Accession: NZ_CP060201
• Organism: Pseudomonas protegens strain H1F5C

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7G7XJK7
• Locus tag: GGI48_RS13615
• Protein ID: WP_016962761.1
• Coordinates: 2955248..2955430 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GGI48_RS13610
• Protein ID: WP_177435155.1
• Coordinates: 2954817..2955251 (-)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GGI48_RS13595	2949833..2951161	-	1329	WP_179598717.1	LLM class flavin-dependent oxidoreductase	-
GGI48_RS13600	2951304..2953562	-	2259	WP_179598719.1	TonB-dependent receptor	-
GGI48_RS13605	2953768..2954814	+	1047	WP_179598721.1	LacI family DNA-binding transcriptional regulator	-
GGI48_RS13610	2954817..2955251	-	435	WP_177435155.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GGI48_RS13615	2955248..2955430	-	183	WP_016962761.1	type II toxin-antitoxin system HicA family toxin	Toxin
GGI48_RS13620	2955694..2955951	+	258	WP_016962760.1	hypothetical protein	-
GGI48_RS13625	2955961..2957922	-	1962	WP_161799155.1	choline transporter BetT	-
GGI48_RS13630	2958404..2959330	-	927	WP_016962758.1	serine acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (14-138)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6859.98 Da
• Isoelectric Point: 10.8547

>T170098 WP_016962761.1 NZ_CP060201:c2955430-2955248 [Pseudomonas protegens]
MRSREMIGKIEADGWYLIAVKGSHHQYKHPWKPGRVTIRHPDADLPRGTINSILKQAGLK

Nucleotide

• Length: 183 bp

>T170098 NZ_CP077082:c1882578-1882291 [Pseudomonas sp. OE 28.3]
ATGACCTATAGCCTTGATTTCGATGCGCGTGCATTGAAGGAGTGGCAAAAGCTCGGCGACACCATTCGTCAGCAGCTCAA
AAAGAAGCTGGCGGCCATCCTGAACAACCCACGTATTGAAGCCAATCGCCTGCATGACCTGCCCGACTGCTACAAAATCA
AGCTACGCAGCAGCGGTTACAGGCTGGTTTATCAGGTGATCGATCAGGAAATCACAGTGGTGGTGGTGGCCATTGATAAA
CGGGAGCGTGAACAGGCTTATCGTAAAGCGGGCGAGCGTTTGAGCTAG

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15956.76 Da
• Isoelectric Point: 4.4600

>AT170098 WP_177435155.1 NZ_CP060201:c2955251-2954817 [Pseudomonas protegens]
MSPLLHEESNDMKFPVVLHKDADSEYGVIVPDVPGCYSAGQTVSQAFENVKQALSLHYEGLVADGEPLPQVHEIDDHLDN
PDYAGGVWGVVEFDVTPYFGKSVRFNATLPEHLLERIDQTVKRDQRYNSRSGFLAAAALRELSA

Nucleotide

• Length: 435 bp

>AT170098 NZ_CP077082:c1882807-1882568 [Pseudomonas sp. OE 28.3]
ATGGCGACTATAAGCATCCGTATCGATGACGACCTGAAAGCGCGCGCCTATCTCGAACTGGAAAAGCTCGGCGTTACGCC
TTCCGAACTGATGCGCCAGGCCCTGCAATACGTGGCGGATCGCGGCCAGCTACCTTTCAAGCCCGTTCTGATGACTGAGG
AAGATGAAGCGTTGATGGCCACCGTCCGGGAGCGATTAGCATCGCCTCAACGGGTAAAGGTTTCTATAGATGACCTATAG

Structures

Toxin

• AlphaFold DB: A0A7G7XJK7