Detailed information of TA system TA170093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 82927..83809
• Replicon: plasmid pMDW1
• Accession: NZ_CP060198
• Organism: Aminobacter sp. MDW-2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H5P29_RS29100
• Protein ID: WP_154384463.1
• Coordinates: 82927..83445 (-)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7W3KUD3
• Locus tag: H5P29_RS29105
• Protein ID: WP_067967357.1
• Coordinates: 83438..83809 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5P29_RS29085	79208..79579	-	372	WP_067968412.1	6-carboxytetrahydropterin synthase	-
H5P29_RS29090	79798..80328	+	531	WP_154384465.1	molybdopterin-dependent oxidoreductase	-
H5P29_RS29095	80339..82756	+	2418	WP_154384464.1	EAL domain-containing protein	-
H5P29_RS29100	82927..83445	-	519	WP_154384463.1	RES domain-containing protein	Toxin
H5P29_RS29105	83438..83809	-	372	WP_067967357.1	DUF2384 domain-containing protein	Antitoxin
H5P29_RS29110	83998..84675	-	678	WP_154384462.1	SMC-Scp complex subunit ScpB	-
H5P29_RS29115	84678..85631	-	954	WP_154384461.1	DUF1403 family protein	-
H5P29_RS29120	85814..87646	-	1833	WP_154384460.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..519487	519487

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-165)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (22-63)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19094.62 Da
• Isoelectric Point: 5.6033

>T170093 WP_154384463.1 NZ_CP060198:c83445-82927 [Aminobacter sp. MDW-2]
MPEAALRQQRTLWRAFVPRWAHMPLSGEGAARFGGRWNPVGSPTLYAACELSTAWAEYNQGFVQHPALIAQLELSDARLA
DLTDAAMLDELGIDAGIHRCEWRSDLDDGRAPQTHLLQQRLLTEGFDGVVYPSFMSPGGSCVALWRWNGPGQPSLKVIDP
DQRLPKTQASWL

Nucleotide

• Length: 519 bp

>T170093 NZ_CP077082:1169833-1170108 [Pseudomonas sp. OE 28.3]
ATGGAGTTGAAGTGGACCAGTAAGGCCTTATCGGATCTGGCTCGACTTTTCGACTTCCTGGCCGTCGTAAATCGCATGGC
GGCGGCGCGTACGGTGCAGTCACTTTCCCAAGCACCTTTGAGCTTGTTAAGTAACCCGCGCATCGGTGAACGCGTTGAAG
AATTTGAACCGCGGGACGTAAGACGACTGTTGGTTGGTCATTACGAAATGCGCTACGAAATTCAAGAATCAACACTCTAT
ATTTTGCGTTTATGGCACGTGCGCGAAGATCGTTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13028.98 Da
• Isoelectric Point: 10.2736

>AT170093 WP_067967357.1 NZ_CP060198:c83809-83438 [Aminobacter sp. MDW-2]
MAAQSLGMSAAHFGEARSQFLSARRVSELLGVTQADLARLVGVARNTLTARSGARKVDQALSPVVRILAMAAEMAGDESR
AAIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA

Nucleotide

• Length: 372 bp

>AT170093 NZ_CP077082:1169567-1169833 [Pseudomonas sp. OE 28.3]
ATGGGCGCCGACACTAAAGTACTGACCGCTCACGTCCCCACCGCCTTGGCGCAAAAAGTCGATCAGATGGCGGCACGGAT
GGATCGTTCGCGGGGCTGGATCGTTAAGCAAGCGCTCGCCGATTGGGTCGATATGGAGGAAGCACGCAGCCGGCTGACAC
GAGAGGCCATGGCCGATGTCGATGCCGGTCGGGTGATTGATCAGCAAGCGGTTCAAGCCTGGGCGGATAGTTTAAGCACT
GATTCGCCGCTGCCGGTACCTCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W3KUD3