Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1773081..1773717 Replicon chromosome
Accession NZ_CP060192
Organism Bacillus sp. PAMC28748

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag H7F26_RS08970 Protein ID WP_003179128.1
Coordinates 1773367..1773717 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag H7F26_RS08965 Protein ID WP_006638778.1
Coordinates 1773081..1773362 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7F26_RS08945 1768196..1769677 + 1482 WP_009330132.1 PH domain-containing protein -
H7F26_RS08950 1769674..1770273 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
H7F26_RS08955 1770616..1771575 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
H7F26_RS08960 1771800..1772969 + 1170 WP_026080763.1 alanine racemase -
H7F26_RS08965 1773081..1773362 + 282 WP_006638778.1 hypothetical protein Antitoxin
H7F26_RS08970 1773367..1773717 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
H7F26_RS08975 1773835..1774662 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
H7F26_RS08980 1774666..1775031 + 366 WP_003179132.1 STAS domain-containing protein -
H7F26_RS08985 1775034..1775435 + 402 WP_003179135.1 anti-sigma regulatory factor -
H7F26_RS08990 1775446..1776453 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
H7F26_RS08995 1776512..1776838 + 327 WP_003179140.1 anti-sigma factor antagonist -
H7F26_RS09000 1776838..1777323 + 486 WP_003179142.1 anti-sigma B factor RsbW -
H7F26_RS09005 1777289..1778080 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
H7F26_RS09010 1778077..1778676 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T170088 WP_003179128.1 NZ_CP060192:1773367-1773717 [Bacillus sp. PAMC28748]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T170088 NZ_CP077081:c1171770-1171519 [Pseudomonas atacamensis]
ATGTCAAAGACTGAAAAACTTCTCGCCAAGCTAATCAACGGGCACAGCGCATTCACTTGGTCCGAGCTTGTCACTCTGTT
AGGTCGTCTTGGTTACTCCCAACTGGAAGGATCCGGTAGCAGGATCAAATTCGACAATGGGGATCCGAACGCATTGATCA
ACCTGCACAAGCCACATCCCGGAAATGAAATCAAAACATACGCAAGACGCCAGATTATCGAGCAACTGAAAACAGGAGGC
CTGATTCCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT170088 WP_006638778.1 NZ_CP060192:1773081-1773362 [Bacillus sp. PAMC28748]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT170088 NZ_CP077081:c1171522-1171181 [Pseudomonas atacamensis]
ATGAGTTCCCAACTGCACTACAAAGGCTATGTTGGCTCTATCGAGGCGAGCACGGAAGATAAGTGCCTGTTCGGAAAACT
CCTTTTCATCAGGGCGCTGGTTAATTATGAAGGACAAACGGTGGCTGAACTGGAAGCAGCCTTTCGCGAGGCGGTAGATG
ACTATTTACAAACCTGTGAGCAGCTCGGGCAGAAGCCTGAAATCCCATGCAAAGGATCGTTCAATGTTCGCATCGGTCAC
GATCTGCATTTAGCAGCGGCTCTGGCGGCAACCCGTCAAAATGTGTCGTTGAATGATCTGACACGTCAAGCACTGAACGA
ATACCTCCAACACCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References