Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1773081..1773717 Replicon chromosome
Accession NZ_CP060192
Organism Bacillus sp. PAMC28748

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag H7F26_RS08970 Protein ID WP_003179128.1
Coordinates 1773367..1773717 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag H7F26_RS08965 Protein ID WP_006638778.1
Coordinates 1773081..1773362 (+) Length 94 a.a.

Genomic Context

H7F26_RS08945H7F26_RS08955H7F26_RS08960H7F26_RS08965H7F26_RS08970H7F26_RS08975H7F26_RS08980H7F26_RS08985H7F26_RS08990H7F26_RS08995H7F26_RS09000H7F26_RS09005H7F26_RS09010H7F26_RS08950
Location: 1768196..1769677 (1482 bp)
Type: Others
Protein ID: WP_009330132.1
Location: 1770616..1771575 (960 bp)
Type: Others
Protein ID: WP_152847888.1
Location: 1771800..1772969 (1170 bp)
Type: Others
Protein ID: WP_026080763.1
Location: 1773081..1773362 (282 bp)
Type: Antitoxin
Protein ID: WP_006638778.1
Location: 1773367..1773717 (351 bp)
Type: Toxin
Protein ID: WP_003179128.1
Location: 1773835..1774662 (828 bp)
Type: Others
Protein ID: WP_003179130.1
Location: 1774666..1775031 (366 bp)
Type: Others
Protein ID: WP_003179132.1
Location: 1775034..1775435 (402 bp)
Type: Others
Protein ID: WP_003179135.1
Location: 1775446..1776453 (1008 bp)
Type: Others
Protein ID: WP_003179137.1
Location: 1776512..1776838 (327 bp)
Type: Others
Protein ID: WP_003179140.1
Location: 1776838..1777323 (486 bp)
Type: Others
Protein ID: WP_003179142.1
Location: 1777289..1778080 (792 bp)
Type: Others
Protein ID: WP_003179144.1
Location: 1778077..1778676 (600 bp)
Type: Others
Protein ID: WP_003179145.1
Location: 1769674..1770273 (600 bp)
Type: Others
Protein ID: WP_003179118.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H7F26_RS089451768196..1769677+1482WP_009330132.1PH domain-containing protein-
H7F26_RS089501769674..1770273-600WP_003179118.1rhomboid family intramembrane serine protease-
H7F26_RS089551770616..1771575+960WP_152847888.1outer membrane lipoprotein carrier protein LolA-
H7F26_RS089601771800..1772969+1170WP_026080763.1alanine racemase-
H7F26_RS089651773081..1773362+282WP_006638778.1hypothetical proteinAntitoxin
H7F26_RS089701773367..1773717+351WP_003179128.1type II toxin-antitoxin system endoribonuclease NdoAToxin
H7F26_RS089751773835..1774662+828WP_003179130.1RsbT co-antagonist protein RsbRA-
H7F26_RS089801774666..1775031+366WP_003179132.1STAS domain-containing protein-
H7F26_RS089851775034..1775435+402WP_003179135.1anti-sigma regulatory factor-
H7F26_RS089901775446..1776453+1008WP_003179137.1PP2C family protein-serine/threonine phosphatase-
H7F26_RS089951776512..1776838+327WP_003179140.1anti-sigma factor antagonist-
H7F26_RS090001776838..1777323+486WP_003179142.1anti-sigma B factor RsbW-
H7F26_RS090051777289..1778080+792WP_003179144.1RNA polymerase sigma factor SigB-
H7F26_RS090101778077..1778676+600WP_003179145.1SpoIIE family protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T170088 WP_003179128.1 NZ_CP060192:1773367-1773717 [Bacillus sp. PAMC28748]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T170088 NZ_CP077081:c1171770-1171519 [Pseudomonas atacamensis]
ATGTCAAAGACTGAAAAACTTCTCGCCAAGCTAATCAACGGGCACAGCGCATTCACTTGGTCCGAGCTTGTCACTCTGTT
AGGTCGTCTTGGTTACTCCCAACTGGAAGGATCCGGTAGCAGGATCAAATTCGACAATGGGGATCCGAACGCATTGATCA
ACCTGCACAAGCCACATCCCGGAAATGAAATCAAAACATACGCAAGACGCCAGATTATCGAGCAACTGAAAACAGGAGGC
CTGATTCCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT170088 WP_006638778.1 NZ_CP060192:1773081-1773362 [Bacillus sp. PAMC28748]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT170088 NZ_CP077081:c1171522-1171181 [Pseudomonas atacamensis]
ATGAGTTCCCAACTGCACTACAAAGGCTATGTTGGCTCTATCGAGGCGAGCACGGAAGATAAGTGCCTGTTCGGAAAACT
CCTTTTCATCAGGGCGCTGGTTAATTATGAAGGACAAACGGTGGCTGAACTGGAAGCAGCCTTTCGCGAGGCGGTAGATG
ACTATTTACAAACCTGTGAGCAGCTCGGGCAGAAGCCTGAAATCCCATGCAAAGGATCGTTCAATGTTCGCATCGGTCAC
GATCTGCATTTAGCAGCGGCTCTGGCGGCAACCCGTCAAAATGTGTCGTTGAATGATCTGACACGTCAAGCACTGAACGA
ATACCTCCAACACCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6I7FHI4

Antitoxin

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Source
ID
Structure
AlphaFold DBM5PDU2

References