Detailed information of TA system TA170084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 6739..7364
• Replicon: plasmid pSLT
• Accession: NZ_CP060170
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain BKQZM9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H7H28_RS23730
• Protein ID: WP_000911322.1
• Coordinates: 6966..7364 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H7H28_RS23725
• Protein ID: WP_000450265.1
• Coordinates: 6739..6966 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7H28_RS23725	6739..6966	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
H7H28_RS23730	6966..7364	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
H7H28_RS23735	7373..9535	-	2163	WP_000009318.1	type IV conjugative transfer system coupling protein TraD	-
H7H28_RS23740	9912..10643	-	732	WP_000782438.1	complement resistance protein TraT	-
H7H28_RS23745	10679..11173	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93813	93813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T170084 WP_000911322.1 NZ_CP060170:6966-7364 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T170084 NZ_CP077080:4307610-4307885 [Pseudomonas alvandae]
ATGGAGTTGAAGTGGACCAGCAAGGCGCTTTCCGACATTGCTCGACTTTATGAGTTTCTGGCTTCGGTAAATCAACCCGC
CGCCGCGCGGACCGTGCAACAACTCACGGCAGCGCCCAGCTCTCTGCTGGTTAACCCGCGAATTGGTGAACGCCTGGAAG
AGTTCGAACCTCGAGACGTACGCAGAATTCAGGTCGGCCATTACGAAATGCGCTATGAAATAGTCGGTTCTACCCTTTAC
CTGCTACGCCTTTGGCACACCCGTGAGGATCGATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT170084 WP_000450265.1 NZ_CP060170:6739-6966 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT170084 NZ_CP077080:4307338-4307610 [Pseudomonas alvandae]
ATGACTACCACTGCGAAGACCCGATCGGTCACGGCTCATGTCCCGGTCCACCTGGCCGAGAAAGTCGACCTGATGGCCGA
GCGACTCGAGCGCTCCAGGAATTGGATCGTCAAACAGGCGTTATCTGCCTGGATCGACCAGGAGGAGGAGCGAAGCCGGC
TGACCCATGAAGCGTTGGCGGACGTGGACGCTGGCCGAGTAATTGACCATCAGGCTGTCCAGGCTTGGGCCGACAGTCTC
AGCACCGACGCCCCGTTACCGGTACCGCGCTGA