Detailed information of TA system TA170083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1116171..1116980
• Replicon: chromosome
• Accession: NZ_CP060160
• Organism: Staphylococcus lugdunensis strain MBAZ2

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: H6Y62_RS05345
• Protein ID: WP_002458758.1
• Coordinates: 1116810..1116980 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: H6Y62_RS05340
• Protein ID: WP_002458757.1
• Coordinates: 1116171..1116770 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6Y62_RS05320	1111758..1113215	+	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-
H6Y62_RS05325	1113208..1113933	+	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
H6Y62_RS05330	1114391..1115533	+	1143	WP_094449181.1	tRNA epoxyqueuosine(34) reductase QueG	-
H6Y62_RS05335	1115535..1116005	+	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
H6Y62_RS05340	1116171..1116770	+	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
H6Y62_RS05345	1116810..1116980	+	171	WP_002458758.1	hypothetical protein	Toxin
H6Y62_RS05350	1117153..1117548	+	396	WP_002458759.1	hypothetical protein	-
H6Y62_RS05355	1117676..1119061	+	1386	WP_002492636.1	class II fumarate hydratase	-
H6Y62_RS05360	1119126..1119962	-	837	WP_002477978.1	RluA family pseudouridine synthase	-
H6Y62_RS05365	1120130..1121242	+	1113	WP_002492606.1	GAF domain-containing sensor histidine kinase	-
H6Y62_RS05370	1121264..1121887	+	624	WP_002492614.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T170083 WP_002458758.1 NZ_CP060160:1116810-1116980 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T170083 NZ_CP077080:1334234-1334578 [Pseudomonas alvandae]
ATGCGAACCTTATTTTTTGAAACGACTACGTTCACTGCCACGGTTGGCCATTACCTGACCGATGATGAATATCGCCTGCT
TCAGTTCTATATGCAGCAGCATCCAGAGGCCGGTGACGTCATGCCACGTACCGGTGGCTTCCGTAAGCTGCGTTGGTTCG
ATGACCGTCGCGGCAAAGGGAAACGAGGTGGACTGCGGGTCATTTATTATTGGTTGAGGCATGATCGTCAGTTCTGGATG
TTTGCGATTTATGACAAGGACGAACTGGAAAACCTGACCTCCGAGCAAGAGAAGACGCTCAAGCGCGCCATAGAAGCTGA
GTTGAAAGTACGAGGTACCTTATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT170083 WP_002458757.1 NZ_CP060160:1116171-1116770 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT170083 NZ_CP077080:1334575-1334889 [Pseudomonas alvandae]
ATGAAAAAGCGTGATCTGTTTGCCGAGATGATGCAAGGCGTCGAGGAGATGGCCGCTCACCGCGAGGGCAAGATTACCCT
TCGCCAGATTTCGATTGAAGACAAGCCGGTTCCCGAGGTGTCGGCCCAGGAAATCGTGGCCCTGCGCGACAGGCTCCATA
TGTCCCAAGCTGTTTTCGCCAAGAGCATCAGGACCAGTCCGGGCACCCTAAGGAACTGGGAGCAGGAAAAGTCCAAGCCT
AACGCCCAGGCGGCTTTGTTGATCAAATTGGTCGAGAAGTTTCCGGATATGGTCGAACGGCTTGGTGCTGTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2