Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 962336..962853 Replicon chromosome
Accession NZ_CP060160
Organism Staphylococcus lugdunensis strain MBAZ2

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag H6Y62_RS04450 Protein ID WP_002461192.1
Coordinates 962503..962853 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag H6Y62_RS04445 Protein ID WP_002461193.1
Coordinates 962336..962506 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H6Y62_RS04420 958161..958643 + 483 WP_002492078.1 PH domain-containing protein -
H6Y62_RS04425 958636..960150 + 1515 WP_002492082.1 PH domain-containing protein -
H6Y62_RS04430 960137..960649 + 513 WP_002461197.1 PH domain-containing protein -
H6Y62_RS04435 960661..961053 + 393 WP_002461196.1 holo-ACP synthase -
H6Y62_RS04440 961101..962249 + 1149 WP_002492086.1 alanine racemase -
H6Y62_RS04445 962336..962506 + 171 WP_002461193.1 hypothetical protein Antitoxin
H6Y62_RS04450 962503..962853 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H6Y62_RS04455 963287..964288 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
H6Y62_RS04460 964379..964705 + 327 WP_002461190.1 anti-sigma factor antagonist -
H6Y62_RS04465 964707..965186 + 480 WP_002492094.1 anti-sigma B factor RsbW -
H6Y62_RS04470 965161..965931 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T170081 WP_002461192.1 NZ_CP060160:962503-962853 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T170081 NZ_CP077080:731261-731566 [Pseudomonas alvandae]
ATGACGGAGATCATTCGAAGCTCTACCTTTTCCGGCTGGCTCTCGAAGCTGGCTGATAGCCGTGCCAGGATGCGTATTCA
GGTTCGAGTCGATCGTATGGCCGATGGGAATCTGGGTGACGTCAAAGCTTTAGGAGAAGGGTTGAGTGAGGCCCGTATCG
ATTACGGTCCGGGCTATCGAATTTATTTCATGCAGCAAGGCCGACAATTGATCATCCTTCTGTGTGGTGGTGACAAAAGC
AGTCAAGCACGTGATATCAAGCAAGCCAGGCTGATCGCAAAATCCTGGCAGGAGCAAAACCCATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT170081 WP_002461193.1 NZ_CP060160:962336-962506 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT170081 NZ_CP077080:731563-731850 [Pseudomonas alvandae]
ATGACCGAACAATTCACTCGCTGGGACTCTGCCGAGTACCTCAAGACCGAAGAGGACATGGCGAACTATTTGGATGCATG
CATGGACGAGGCAGGAGATGACCCCGCATTCATTGCTAAAGCCCTAGGGACCATTGCACGAGCTCGTGGGATGACCCAGG
TGGCCCGTGACGCGGGCCTCTCTCGGGAAAACCTTTATCGCGCCTTGTCAGGGGAAGGAAACCCTGAGTTCGGTACTATT
TTGAAAGTTGTTAAAGCGTTGGGGCTGAAACTGCATGCCAGTACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References