Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 950938..951456 Replicon chromosome
Accession NZ_CP060160
Organism Staphylococcus lugdunensis strain MBAZ2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag H6Y62_RS04390 Protein ID WP_002492077.1
Coordinates 951244..951456 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag H6Y62_RS04385 Protein ID WP_002492098.1
Coordinates 950938..951231 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H6Y62_RS04365 946538..947176 + 639 WP_002492090.1 thiamine phosphate synthase -
H6Y62_RS04370 947266..948141 + 876 WP_002461212.1 membrane protein insertase YidC -
H6Y62_RS04375 948525..949166 - 642 WP_002492092.1 HD domain-containing protein -
H6Y62_RS04380 949288..950772 - 1485 WP_002478972.1 cardiolipin synthase -
H6Y62_RS04385 950938..951231 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
H6Y62_RS04390 951244..951456 + 213 WP_002492077.1 heavy-metal-associated domain-containing protein Toxin
H6Y62_RS04395 951547..951684 + 138 WP_002461206.1 hypothetical protein -
H6Y62_RS04400 952098..953288 - 1191 WP_002461205.1 rod shape-determining protein RodA -
H6Y62_RS04405 953644..954714 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
H6Y62_RS04410 954732..956090 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T170080 WP_002492077.1 NZ_CP060160:951244-951456 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T170080 NZ_CP060160:951244-951456 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAATGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTCGAAACATCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT170080 WP_002492098.1 NZ_CP060160:950938-951231 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT170080 NZ_CP060160:950938-951231 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References