Detailed information of TA system TA170077

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1276124..1276655
• Replicon: chromosome
• Accession: NZ_CP060159
• Organism: Xylella fastidiosa subsp. fastidiosa strain GV230

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: XFGV230_RS05605
• Protein ID: WP_004090909.1
• Coordinates: 1276374..1276655 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: XFGV230_RS05600
• Protein ID: WP_004090907.1
• Coordinates: 1276124..1276387 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFGV230_RS05575	1271350..1272528	-	1179	WP_128734780.1	phage tail sheath family protein	-
XFGV230_RS05580	1272593..1274185	-	1593	WP_159241645.1	hypothetical protein	-
XFGV230_RS05585	1274193..1274750	-	558	WP_004086970.1	phage tail protein I	-
XFGV230_RS05590	1274743..1275636	-	894	WP_160176385.1	baseplate J/gp47 family protein	-
XFGV230_RS05595	1275636..1275974	-	339	WP_004090694.1	GPW/gp25 family protein	-
XFGV230_RS05600	1276124..1276387	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XFGV230_RS05605	1276374..1276655	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
XFGV230_RS05610	1276692..1277279	-	588	WP_011097612.1	phage baseplate assembly protein V	-
XFGV230_RS05615	1277276..1277818	-	543	WP_011097613.1	hypothetical protein	-
XFGV230_RS05620	1277794..1278315	-	522	WP_011097614.1	hypothetical protein	-
XFGV230_RS05625	1278312..1278635	-	324	WP_011097935.1	hypothetical protein	-
XFGV230_RS05630	1278635..1278895	-	261	WP_038232801.1	hypothetical protein	-
XFGV230_RS05635	1278913..1280787	-	1875	WP_185864772.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1262711..1308897	46186

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T170077 WP_004090909.1 NZ_CP060159:1276374-1276655 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T170077 NZ_CP077079:c877908-877606 [Pseudomonas asgharzadehiana]
ATGATTCACTTCAAGAGGTCTGATGAGTTTCAGGAATGGCTTTATTCGTTGCGCAGTCAACCCGCCCATGGACGCGTACT
AACAAGATTGGATAACGCAAGAATGGGTAATTTTGGAGACTGCGAAAACGTCGGAAATGGCATATCCGAAATGCGCATCC
ACTATGGCCCTGGATACCGTGTGTACTTCAAGCGTGTAGGTGAGGTGGTTTACCTATTGCTGACAGGTGGCGATAAATCA
ACGCAAAAACGCGACATTGAGCGCGCTAAAGCAATTGCCGATGAATTTGAGAGAAAGGAGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT170077 WP_004090907.1 NZ_CP060159:1276124-1276387 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT170077 NZ_CP077079:c877602-877315 [Pseudomonas asgharzadehiana]
ATGACTCAATTTAACGATTTCGACATAGCCGAACACCTGACGAGCCCTCAGGACATTGCGGGGTATCTGGAAGCTTCTTT
CGAGGAGGACGCCGGTGACGGGCTGCTGATTCGTTCAGCGCTCAACAACATCGCCCGCGCCCAAGGCATGACCCAAATCG
CCCGCGACGCAGGTCTCGGACGGGAAAGTCTATACAAAGCCCTCTCCAGCACTGGCAATCCTGAGTTCGCGACTATCATG
AAGGTCATGAAGGCGTTAGGCCTGAGACTTCGCGCCACCGCTATCTGA

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2