Detailed information of TA system TA170075

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1161649..1162126
• Replicon: chromosome
• Accession: NZ_CP060159
• Organism: Xylella fastidiosa subsp. fastidiosa strain GV230

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: Q87CA4
• Locus tag: XFGV230_RS04915
• Protein ID: WP_011097988.1
• Coordinates: 1161860..1162126 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7G7TPD2
• Locus tag: XFGV230_RS04910
• Protein ID: WP_004091377.1
• Coordinates: 1161649..1161876 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFGV230_RS04870	1156786..1157921	-	1136	Protein_941	baseplate J/gp47 family protein	-
XFGV230_RS04875	1158020..1158316	+	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	-
XFGV230_RS04880	1158320..1158625	+	306	WP_004089254.1	putative addiction module antidote protein	-
XFGV230_RS04885	1158636..1158989	-	354	WP_011097986.1	hypothetical protein	-
XFGV230_RS04890	1158986..1159627	-	642	WP_004090764.1	hypothetical protein	-
XFGV230_RS04895	1159624..1160454	-	831	WP_004090766.1	hypothetical protein	-
XFGV230_RS04900	1160451..1160768	-	318	WP_011097873.1	hypothetical protein	-
XFGV230_RS04905	1160768..1161538	-	771	WP_004090769.1	hypothetical protein	-
XFGV230_RS04910	1161649..1161876	+	228	WP_004091377.1	hypothetical protein	Antitoxin
XFGV230_RS04915	1161860..1162126	+	267	WP_011097988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFGV230_RS04920	1162137..1164026	-	1890	WP_011097989.1	hypothetical protein	-
XFGV230_RS04925	1163983..1164147	-	165	WP_162849007.1	hypothetical protein	-
XFGV230_RS04930	1164174..1164596	-	423	WP_012382587.1	hypothetical protein	-
XFGV230_RS04935	1164593..1165030	-	438	WP_011097990.1	DUF3277 family protein	-
XFGV230_RS04940	1165040..1166536	-	1497	WP_038232978.1	DUF3383 domain-containing protein	-
XFGV230_RS04945	1166537..1167070	-	534	WP_004090297.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1155062..1195772	40710

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10163.79 Da
• Isoelectric Point: 10.6086

>T170075 WP_011097988.1 NZ_CP060159:1161860-1162126 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T170075 NZ_CP077079:c527594-527412 [Pseudomonas asgharzadehiana]
ATGCAGAGTCGCGAAGTGATCAAGAGGCTGATAGATGATGGATGGGTCAAGGTAAAGGGTGGTGATGGTAGCCACCAGCA
GTTCAAACACCCAACCAAGAAGGGTCGCGTTACGGTTCCACATCCCCAAAAGGATGTTCCACTGGGGACCCTTCGAAGCA
TCTGGAAGCAAGCCGGTCTATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8615.63 Da
• Isoelectric Point: 5.0958

>AT170075 WP_004091377.1 NZ_CP060159:1161649-1161876 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT170075 NZ_CP077079:c527332-526892 [Pseudomonas asgharzadehiana]
ATGAAATACGTAGTTGTTTTGCATAAAGATGAAGGCTCCGATTACGGAGTAACCGTGCCTGATGTTCCAGGTTGCTTCTC
TGCAGGCGAAACTATTGATGAAGCACTACGGAACGTTGTTGATGCGCTGTCGATGCAGTTTGAAGGTTTAGTGGAAGACG
GTGAACCGATGCCAGAAGCACAAAGCATCGAGCACCATAGGAAAGATCCAGACTATGCCGATGGCATCTGGGCTTTCGTA
GAGTTTGATACAACCCCGTACTATGGAAAAGCAGTGAGATTTAATGCATCTCTACCTGAAGGGCTACTAAAAAAAATCGA
TGATCGAGTAAAGGAGGGTAATTCTTACGCTTCACGATCTGGATTTCTAGCAACAGCAGCGCTGCATGAACTTGCTAAAT
ACTTGGAAGAAGATGTCAAATCTAGAAGAGTTGCTAGCTGA

Structures

Toxin

• AlphaFold DB: A0A060HDH1

Antitoxin

• AlphaFold DB: A0A7G7TPD2