Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1740731..1741399 Replicon chromosome
Accession NZ_CP060156
Organism Streptococcus pneumoniae strain PZ900700608

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H6X75_RS08645 Protein ID WP_025169096.1
Coordinates 1741220..1741399 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag H6X75_RS08640 Protein ID WP_000961810.1
Coordinates 1740731..1741183 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H6X75_RS08615 (H6X75_08620) 1736621..1737364 - 744 WP_001188207.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
H6X75_RS08620 (H6X75_08625) 1737366..1738316 - 951 WP_000451134.1 50S ribosomal protein L11 methyltransferase -
H6X75_RS08625 (H6X75_08630) 1738454..1738882 - 429 WP_000401988.1 NUDIX hydrolase -
H6X75_RS08630 (H6X75_08635) 1738884..1739951 - 1068 WP_000719721.1 site-2 protease family protein -
H6X75_RS08635 (H6X75_08640) 1739970..1740440 - 471 WP_000257084.1 DUF3013 family protein -
H6X75_RS08640 (H6X75_08645) 1740731..1741183 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H6X75_RS08645 (H6X75_08650) 1741220..1741399 - 180 WP_025169096.1 type II toxin-antitoxin system HicA family toxin Toxin
H6X75_RS08650 (H6X75_08655) 1741536..1741715 - 180 WP_001809903.1 hypothetical protein -
H6X75_RS08655 (H6X75_08660) 1741880..1742118 - 239 Protein_1720 hypothetical protein -
H6X75_RS08660 (H6X75_08665) 1742388..1743659 + 1272 WP_001113210.1 replication-associated recombination protein A -
H6X75_RS08670 (H6X75_08675) 1744206..1745525 - 1320 WP_000502547.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6578.75 Da        Isoelectric Point: 10.8214

>T170070 WP_025169096.1 NZ_CP060156:c1741399-1741220 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 180 bp

>T170070 NZ_CP077077:c1588741-1588436 [Pseudomonas maumuensis]
ATGACTGAAACGTTCCATGAATTCGACGCCGCCGCCTATCTGACTTCACCGGAAACCATCGCGCAGTTCATGACCGATGC
ATTGGAGACAGGGGATGCAGCCTACGTAGCAAAAGCCGTGGGCGTGGTGGCTCGCGCCAGGGGCATGAGTGAACTGGCAA
AGGAAACAGGCCTGTCTCGCGAGCAGCTTTACCGCTCGTTCAGTGAACACGGCAACCCAACGCTCAAATCGTTCCTGACT
GTAATGAAAGCGTTGGGAATAGACATGGCTGCCAGACCCCACTTATCCCAGCAAGGTGCAGGCTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT170070 WP_000961810.1 NZ_CP060156:c1741183-1740731 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT170070 NZ_CP077077:c1589036-1588734 [Pseudomonas maumuensis]
ATGAAAACCATCGAATCCAGCAGTTTCAGGCATTGGCTGATCGGGCTTCGGGATGCCACGGCAAGGGCCAGAATCGTCGC
TCGTGTCAACCGACTCAAGGAAGGGCTAGCGGGTGACGTTTCACCGGTCGGCCATGGCATGAGTGAGCTGAGAGTCCATT
ACGGCCCAGGCTATCGGGTGTATTTTCACCAATACGGCGATACCTTGATCGTCCTGCTTTGCGGCGGCGACAAAAGCAGC
CAGCAACGGGACATCAAGGCAGCCCGGCAGATCCTGCAGTCGTGGAGGATGCAAAATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References