Detailed information of TA system TA170064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1772045..1772821
• Replicon: chromosome
• Accession: NZ_CP060141
• Organism: Staphylococcus aureus strain 2868B2

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: H5U44_RS09025
• Protein ID: WP_000031108.1
• Coordinates: 1772669..1772821 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: H5U44_RS09020
• Protein ID: WP_001251230.1
• Coordinates: 1772045..1772644 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5U44_RS09000 (1767961)	1767961..1769418	+	1458	WP_000649908.1	ABC transporter permease subunit	-
H5U44_RS09005 (1769411)	1769411..1770133	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
H5U44_RS09010 (1770284)	1770284..1771411	+	1128	WP_031590038.1	tRNA epoxyqueuosine(34) reductase QueG	-
H5U44_RS09015 (1771416)	1771416..1771886	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
H5U44_RS09020 (1772045)	1772045..1772644	+	600	WP_001251230.1	hypothetical protein	Antitoxin
H5U44_RS09025 (1772669)	1772669..1772821	+	153	WP_000031108.1	SAS053 family protein	Toxin
H5U44_RS09030 (1773657)	1773657..1774052	+	396	WP_000901023.1	hypothetical protein	-
H5U44_RS09035 (1774248)	1774248..1775633	+	1386	WP_000116229.1	class II fumarate hydratase	-
H5U44_RS09040 (1776085)	1776085..1776906	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T170064 WP_000031108.1 NZ_CP060141:1772669-1772821 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T170064 NZ_CP077075:4543794-4544069 [Pseudomonas xanthosomae]
ATGGAGTTGAAGTGGACCAGCAAGGGGCTGTCCGACCTGGCGCGCCTGCATGAATTTCTGGCTGCCGTGAACCCATCTGC
TGCAGTGCGCACCGTTCAACAGCTCGTAGCAGCACCTAACGTTCTGCTGACCAACCCCCGGGTAGGAGAGCGGCTGGAAG
AATTCGAACCACGCGAAGTGCGACGGAGTCTGGTTGGCCATTACGAAATGCGGTATGAGATCACGCCTTCTTGCATCTAC
CTGCTGCGCCTGTGGCATACCCGCGAAGAACGCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22369.51 Da
• Isoelectric Point: 4.9728

>AT170064 WP_001251230.1 NZ_CP060141:1772045-1772644 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKYAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT170064 NZ_CP077075:4543522-4543794 [Pseudomonas xanthosomae]
ATGACTATCGCCGCCAAAACCCGTTCAGTTACGGCCCATGTACCCGTGGAACTGGCCGAGCGCATCGATGAAATCGCCAC
CCGGCTCGAGCGTTCGAAAAACTGGATCGTCAAACAGGCGCTGTCTGACTGGCTGGCACAGGAAGATGAACGTAACCGAC
TGACCCGTGAAGCACTGGCAGATGTCGATGCCGGCAGAGTAATCGATCATCAGTCTGTTCAGGCTTGGGCTGAAAGCCTG
GGCACAGACTCCCCCCTGCCGGTACCTCGTTGA

Structures

Toxin

• AlphaFold DB: X5E2E6