Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1539952..1540466 Replicon chromosome
Accession NZ_CP060141
Organism Staphylococcus aureus strain 2868B2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag H5U44_RS07630 Protein ID WP_000581793.1
Coordinates 1540257..1540466 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag H5U44_RS07625 Protein ID WP_000138932.1
Coordinates 1539952..1540245 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5U44_RS07605 (1535414) 1535414..1536055 + 642 WP_072529239.1 thiamine phosphate synthase -
H5U44_RS07610 (1536141) 1536141..1537013 + 873 WP_000725802.1 membrane protein insertase YidC -
H5U44_RS07615 (1537627) 1537627..1538274 - 648 WP_031590210.1 HD domain-containing protein -
H5U44_RS07620 (1538302) 1538302..1539786 - 1485 WP_000571549.1 cardiolipin synthase -
H5U44_RS07625 (1539952) 1539952..1540245 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
H5U44_RS07630 (1540257) 1540257..1540466 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
H5U44_RS07635 (1540594) 1540594..1540731 + 138 WP_000828354.1 Lmo0850 family protein -
H5U44_RS07640 (1540994) 1540994..1542196 - 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
H5U44_RS07645 (1542514) 1542514..1543584 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
H5U44_RS07650 (1543599) 1543599..1544957 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T170055 WP_000581793.1 NZ_CP060141:1540257-1540466 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T170055 NZ_CP077074:c1746072-1745788 [Pseudomonas sessilinigenes]
ATGCACATTGAGTGGCTGCGAACAGCCCTGAAAAACCTGGATGACGAGGCGCGTTACATTGCCCAGGACAATCCTGAAGC
CGCCAGGGAGTTCGTGCAGACCCTGCTCACTGGCATCGGGCATTTGGCCCGTTTTCCGGCCAGCGGGCGCGAAGGTCGGC
TACCCGGTACCCGAGAATGGGTCGTGCCTGGATGGCCTTATCTGATTCCCTATCGAGTGCGCGGTAGTCGGTTGCAGATA
CTGCGCATCTTCCACACTCGCCGCCAGCCTCCGCAGCGCTGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT170055 WP_000138932.1 NZ_CP060141:1539952-1540245 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT170055 NZ_CP077074:c1746301-1746062 [Pseudomonas sessilinigenes]
ATGTCCATCATGTCCCTGCGCCTGCCCGACGAAATGGCTGAAACCCTTGCTCTGCTGGCGAAAGCGACAGGGCGTAGCAA
GTCGTTCCTGGCGGTGGATGCGTTGCGTGAATACCTCGCCCGGGAAGCCTGGCAGATCGAGGAGATCCAAAAGGCGCTCG
GGGAAGCTGATGCGGGGGATTTCGCCAGCGCGGAGGAAGTAGCGGCCATCACGGGTAAATGGACCGGCAATGCACATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References