Detailed information of TA system TA170041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YefM
• Location: 1414194..1414719
• Replicon: chromosome
• Accession: NZ_CP060138
• Organism: Rickettsia sp. Tillamook 23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H6P87_RS07515
• Protein ID: WP_202069498.1
• Coordinates: 1414194..1414478 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H6P87_RS07520
• Protein ID: WP_202069499.1
• Coordinates: 1414468..1414719 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6P87_RS07485	1409387..1410025	+	639	WP_202069495.1	outer membrane lipoprotein carrier protein LolA	-
H6P87_RS07495	1410295..1411824	+	1530	WP_202069496.1	DNA polymerase III subunit gamma/tau	-
H6P87_RS07500	1411836..1412159	+	324	WP_011271665.1	YbaB/EbfC family nucleoid-associated protein	-
H6P87_RS07505	1412324..1413019	-	696	WP_202069497.1	TIGR02281 family clan AA aspartic protease	-
H6P87_RS07510	1413034..1414032	-	999	WP_202070167.1	serine hydrolase	-
H6P87_RS07515	1414194..1414478	-	285	WP_202069498.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H6P87_RS07520	1414468..1414719	-	252	WP_202069499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H6P87_RS07525	1414789..1415511	-	723	WP_202069500.1	amino acid ABC transporter ATP-binding protein	-
H6P87_RS07530	1415662..1416426	-	765	WP_202069501.1	MBL fold metallo-hydrolase	-
H6P87_RS07535	1416441..1417109	+	669	WP_202070168.1	phosphatase PAP2 family protein	-
H6P87_RS07540	1417230..1418321	+	1092	WP_202070169.1	LptF/LptG family permease	-
H6P87_RS07545	1418289..1418372	-	84	WP_202070170.1	palindromic element RPE5 domain-containing protein	-
H6P87_RS07550	1418365..1418454	-	90	WP_202069502.1	palindromic element RPE5 domain-containing protein	-
H6P87_RS07555	1418467..1418931	-	465	WP_202069503.1	DNA polymerase III subunit chi	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-75)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11037.99 Da
• Isoelectric Point: 10.7131

>T170041 WP_202069498.1 NZ_CP060138:c1414478-1414194 [Rickettsia tillamookensis]
MTYSLEFIPIARKEWDKLGSTIKEQFKKKLSERLKSPHVPKDAVNGGNNLYKIKLRSVGYRLVYEVDDKRIIVLVLAIGK
RNRNEVYNKLFSRI

Nucleotide

• Length: 285 bp

>T170041 NZ_CP077061:c1040763-1040494 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9329.76 Da
• Isoelectric Point: 5.6863

>AT170041 WP_202069499.1 NZ_CP060138:c1414719-1414468 [Rickettsia tillamookensis]
MEHIYANLTVSISEFKKSPTALLDKASGEPVALLNHNKPTAYLISAELYARIIEALDDNYLLELSKTRLKDKKEAIKVDI
NDL

Nucleotide

• Length: 252 bp

>AT170041 NZ_CP077061:c1040500-1039979 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA