Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 1317662..1318278 Replicon chromosome
Accession NZ_CP060138
Organism Rickettsia sp. Tillamook 23

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H6P87_RS07055 Protein ID WP_202069426.1
Coordinates 1317662..1317922 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H6P87_RS07060 Protein ID WP_011271587.1
Coordinates 1317919..1318278 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H6P87_RS07025 1312751..1313629 - 879 WP_202069403.1 HEPN domain-containing protein -
H6P87_RS07030 1313643..1314515 - 873 WP_202069405.1 Rpn family recombination-promoting nuclease/putative transposase -
H6P87_RS07035 1314596..1315075 - 480 WP_202069407.1 SH3 domain-containing protein -
H6P87_RS07040 1315068..1316795 - 1728 WP_202069420.1 cation:proton antiporter -
H6P87_RS07045 1316792..1317118 - 327 WP_202069423.1 ribosome silencing factor -
H6P87_RS07050 1317283..1317522 + 240 WP_040256476.1 BolA family transcriptional regulator -
H6P87_RS07055 1317662..1317922 + 261 WP_202069426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H6P87_RS07060 1317919..1318278 + 360 WP_011271587.1 helix-turn-helix transcriptional regulator Antitoxin
H6P87_RS07065 1318401..1318847 - 447 WP_202069428.1 ferritin-like domain-containing protein -
H6P87_RS07070 1319105..1319275 + 171 WP_202069431.1 hypothetical protein -
H6P87_RS07075 1319478..1320746 - 1269 WP_202070157.1 autotransporter outer membrane beta-barrel domain-containing protein -
H6P87_RS07080 1321003..1321869 - 867 WP_202069437.1 hypothetical protein -
H6P87_RS07085 1322661..1323131 - 471 Protein_1381 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Cro/C1-type helix-turn-helix domain

(65-119)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10202.16 Da        Isoelectric Point: 10.6178

>T170040 WP_202069426.1 NZ_CP060138:1317662-1317922 [Rickettsia tillamookensis]
MQYKLSFSKTALKNLLKISINKRKAILEKLEQLKLNPYKENNNIKKLIGYDGYRLRIGDYRVIYRINKGKLEILVINVDV
RGEVYK

Download         Length: 261 bp

>T170040 NZ_CP077061:1038492-1038770 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13799.99 Da        Isoelectric Point: 6.9804

>AT170040 WP_011271587.1 NZ_CP060138:1317919-1318278 [Rickettsia tillamookensis]
MSNKHIIEYQGKPAFVVIPFNEYQELINKKQCITDETLYAEAIAKNEEYFPEDLVQKILNGENPIKVYREYRGLSQEQLA
IKIGKTKQYISFIEKGLRKGTIDTLKKLSTVLNVDLDML

Download         Length: 360 bp

>AT170040 NZ_CP077061:1038211-1038495 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References