Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 8115..8637 Replicon plasmid pYUHAP5-2
Accession NZ_CP060136
Organism Salmonella enterica subsp. enterica serovar London strain HA1-SP5

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag H3A31_RS23520 Protein ID WP_000220561.1
Coordinates 8115..8396 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag H3A31_RS23525 Protein ID WP_000121743.1
Coordinates 8386..8637 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3A31_RS23490 3591..3827 - 237 Protein_3 hypothetical protein -
H3A31_RS23495 3848..4642 - 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
H3A31_RS23500 4671..6101 - 1431 Protein_5 IS4-like element IS50R family transposase -
H3A31_RS23505 6221..6409 + 189 WP_000957857.1 hypothetical protein -
H3A31_RS23510 6419..7618 + 1200 WP_000948429.1 IS91 family transposase -
H3A31_RS23515 7784..7876 + 93 Protein_8 IS6 family transposase -
H3A31_RS23520 8115..8396 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3A31_RS23525 8386..8637 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
H3A31_RS23530 9872..10711 + 840 WP_024129959.1 replication initiation protein -
H3A31_RS23535 10732..11574 + 843 WP_188016585.1 replication initiation protein -
H3A31_RS23540 11578..12024 + 447 WP_001074384.1 hypothetical protein -
H3A31_RS23545 12092..12514 + 423 WP_179292036.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57187 57187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T170038 WP_000220561.1 NZ_CP060136:c8396-8115 [Salmonella enterica subsp. enterica serovar London]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T170038 NZ_CP077061:73881-74378 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 12380.85 Da        Isoelectric Point: 5.5500

>AT170038 WP_000121743.1 NZ_CP060136:c8637-8386 [Salmonella enterica subsp. enterica serovar London]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Download         Length: 252 bp

>AT170038 NZ_CP077061:73612-73884 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References