Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 16624..17146 Replicon plasmid pYUHAP1
Accession NZ_CP060133
Organism Salmonella enterica subsp. enterica serovar London strain HA3-IN1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag H2O76_RS22955 Protein ID WP_000220561.1
Coordinates 16865..17146 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag H2O76_RS22950 Protein ID WP_000121743.1
Coordinates 16624..16875 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2O76_RS22930 12747..13169 - 423 WP_179292036.1 DNA distortion polypeptide 3 -
H2O76_RS22935 13237..13683 - 447 WP_001074384.1 hypothetical protein -
H2O76_RS22940 13687..14529 - 843 WP_188016585.1 replication initiation protein -
H2O76_RS22945 14550..15389 - 840 WP_024129959.1 replication initiation protein -
H2O76_RS22950 16624..16875 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
H2O76_RS22955 16865..17146 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2O76_RS22960 17385..17477 - 93 Protein_19 IS6 family transposase -
H2O76_RS22965 17643..18842 - 1200 WP_000948429.1 IS91 family transposase -
H2O76_RS22970 18852..19040 - 189 WP_000957857.1 hypothetical protein -
H2O76_RS22975 19160..20590 + 1431 Protein_22 IS4-like element IS50R family transposase -
H2O76_RS22980 20619..21413 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
H2O76_RS22985 21434..21670 + 237 Protein_24 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..176767 176767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T170037 WP_000220561.1 NZ_CP060133:16865-17146 [Salmonella enterica subsp. enterica serovar London]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T170037 NZ_CP077061:71981-72250 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT170037 WP_000121743.1 NZ_CP060133:16624-16875 [Salmonella enterica subsp. enterica serovar London]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp

>AT170037 NZ_CP077061:71710-71988 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References