Detailed information of TA system TA170036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 772093..772724
• Replicon: chromosome
• Accession: NZ_CP060131
• Organism: Pseudonocardia sp. CGMCC 4.1532

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H6H00_RS03805
• Protein ID: WP_185719980.1
• Coordinates: 772093..772497 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H6H00_RS03810
• Protein ID: WP_185719981.1
• Coordinates: 772494..772724 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6H00_RS03795	768635..771208	+	2574	WP_185719978.1	phosphoenolpyruvate synthase	-
H6H00_RS03800	771252..772085	+	834	WP_185719979.1	MarR family transcriptional regulator	-
H6H00_RS03805	772093..772497	-	405	WP_185719980.1	PIN domain-containing protein	Toxin
H6H00_RS03810	772494..772724	-	231	WP_185719981.1	hypothetical protein	Antitoxin
H6H00_RS03815	772760..773833	-	1074	WP_185719982.1	redox-regulated ATPase YchF	-
H6H00_RS03820	773985..774605	+	621	WP_185719983.1	hypothetical protein	-
H6H00_RS03825	774612..775277	-	666	WP_185719984.1	response regulator transcription factor	-
H6H00_RS03830	775274..776731	-	1458	WP_185719985.1	HAMP domain-containing histidine kinase	-
H6H00_RS03835	776858..777139	-	282	WP_185722931.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (3-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 13982.05 Da
• Isoelectric Point: 5.8124

>T170036 WP_185719980.1 NZ_CP060131:c772497-772093 [Pseudonocardia sp. CGMCC 4.1532]
VTTHLLDADVLIALTVADHEHHARASAWAAGIGEFAVCPVVEGALVRFLVRVGESAAVAQQVLRAVHALPGCVLWPDSLS
YAAADLSRVRGHRQVTDAYLVGLVAARSDALLATLDEGLAQSHPELALLVPAAP

Nucleotide

• Length: 405 bp

>T170036 NZ_CP077061:c68270-68004 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8116.28 Da
• Isoelectric Point: 7.0131

>AT170036 WP_185719981.1 NZ_CP060131:c772724-772494 [Pseudonocardia sp. CGMCC 4.1532]
VRTTVDLPPAVHRRAQEIAKRRGLSLSAVVAELTVRGLAQLGEPVVIGTDERSGFPVVTIGRRVTSEQVAAALDEE

Nucleotide

• Length: 231 bp

>AT170036 NZ_CP077061:c68017-67772 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA