170034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 4926..5623 Replicon plasmid pSYA3-2
Accession NZ_CP060125
Organism Sphingobium yanoikuyae strain A3

Toxin (Protein)


Gene name tad Uniprot ID T0J3S2
Locus tag H3V42_RS32840 Protein ID WP_013041565.1
Coordinates 4926..5300 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID T0G937
Locus tag H3V42_RS32845 Protein ID WP_006964370.1
Coordinates 5297..5623 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V42_RS32815 619..1383 + 765 WP_001389365.1 IS6-like element IS6100 family transposase -
H3V42_RS32820 1730..2047 + 318 WP_022684651.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
H3V42_RS32825 2122..3393 + 1272 WP_185707998.1 cytochrome P450 -
H3V42_RS32830 3495..4259 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
H3V42_RS32835 4323..4670 + 348 Protein_5 IS6-like element IS6100 family transposase -
H3V42_RS32840 4926..5300 + 375 WP_013041565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3V42_RS32845 5297..5623 + 327 WP_006964370.1 helix-turn-helix domain-containing protein Antitoxin
H3V42_RS32850 5623..5865 + 243 WP_006964372.1 hypothetical protein -
H3V42_RS32855 5858..6157 + 300 WP_006964373.1 hypothetical protein -
H3V42_RS32860 6178..7290 - 1113 WP_006964375.1 IncP-type conjugative transfer protein TrbN -
H3V42_RS32865 7293..8969 - 1677 WP_106000993.1 P-type conjugative transfer protein TrbL -
H3V42_RS32870 9019..9201 - 183 WP_006964379.1 hypothetical protein -
H3V42_RS32875 9211..9933 - 723 WP_106000994.1 P-type conjugative transfer protein TrbJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..71501 71501


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-94)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13960.67 Da        Isoelectric Point: 9.4885

>T170034 WP_013041565.1 NZ_CP060125:4926-5300 [Sphingobium yanoikuyae]
MDTERPVRWVASSKRDFREFPDDVQDVMGYALHLAQQGGQHASTKPLKGFGGAGVVEIIDDHQGDTFRTVYTVKFAEAVY
VLHAFQKKSKQGKATPQADMDLIRTRLKSAEEHHRQHQTPRGTA

Download         Length: 375 bp

>T170034 NZ_CP077061:52294-52593 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11792.57 Da        Isoelectric Point: 7.1681

>AT170034 WP_006964370.1 NZ_CP060125:5297-5623 [Sphingobium yanoikuyae]
MSAQDEIIEEGSGNVFADLGFADPDTHLLKAQLVTRVAEAMQERKLTQIAAAKVTGSTQPELSRILRGQFRSVSVERLLA
MLTRLGCKVDIVVRPQGRTTESAVIHFA

Download         Length: 327 bp

>AT170034 NZ_CP077061:52055-52297 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J7XHG4

Antitoxin

Source ID Structure
AlphaFold DB A0A0J8A803

References