Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 4679042..4679582 Replicon chromosome
Accession NZ_CP060122
Organism Sphingobium yanoikuyae strain A3

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H3V42_RS22365 Protein ID WP_185703971.1
Coordinates 4679042..4679332 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag H3V42_RS22370 Protein ID WP_185703973.1
Coordinates 4679346..4679582 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V42_RS22340 4674239..4675192 + 954 WP_185703965.1 quinoprotein relay system zinc metallohydrolase 1 -
H3V42_RS22345 4675206..4676141 - 936 WP_136186654.1 L-lactate dehydrogenase -
H3V42_RS22350 4676158..4676973 - 816 WP_185707730.1 CoA ester lyase -
H3V42_RS22355 4677051..4678022 + 972 WP_185703967.1 SPFH/Band 7/PHB domain protein -
H3V42_RS22360 4678483..4678929 + 447 WP_185703969.1 NfeD family protein -
H3V42_RS22365 4679042..4679332 - 291 WP_185703971.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3V42_RS22370 4679346..4679582 - 237 WP_185703973.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
H3V42_RS22375 4679765..4681030 - 1266 WP_185703975.1 hypothetical protein -
H3V42_RS22380 4681180..4681674 + 495 WP_185703977.1 hypothetical protein -
H3V42_RS22385 4681813..4683648 + 1836 WP_185703979.1 DUF885 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10627.03 Da        Isoelectric Point: 7.2735

>T170032 WP_185703971.1 NZ_CP060122:c4679332-4679042 [Sphingobium yanoikuyae]
VRRLLFTPAAQADLSDIWDYSAATWGVDQADLYIDAIRDVCLALADGRRPGLPVDVRAGYRKAPAGSHMIYYRDGGDHLA
IVRVLHGRQDTGRYLA

Download         Length: 291 bp

>T170032 NZ_CP077061:c32795-32508 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8371.32 Da        Isoelectric Point: 5.6317

>AT170032 WP_185703973.1 NZ_CP060122:c4679582-4679346 [Sphingobium yanoikuyae]
MARNTSVTIGDHFTRFISDQVQTGRYGSASDVVRAGLRLLEEHEAQVQALQAALIAGEESGAATPFDFEAFKAAKRGC

Download         Length: 237 bp

>AT170032 NZ_CP077061:c32497-32180 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References