Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 4507824..4508521 Replicon chromosome
Accession NZ_CP060122
Organism Sphingobium yanoikuyae strain A3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H3V42_RS21535 Protein ID WP_185703815.1
Coordinates 4507824..4508255 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H3V42_RS21540 Protein ID WP_159365511.1
Coordinates 4508252..4508521 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V42_RS21515 4503856..4504227 - 372 WP_004207946.1 glycine cleavage system protein GcvH -
H3V42_RS21520 4504254..4505417 - 1164 WP_010336292.1 glycine cleavage system aminomethyltransferase GcvT -
H3V42_RS21525 4505794..4506078 - 285 WP_010336291.1 hypothetical protein -
H3V42_RS21530 4506184..4507824 - 1641 WP_185703814.1 recombinase family protein -
H3V42_RS21535 4507824..4508255 - 432 WP_185703815.1 type II toxin-antitoxin system VapC family toxin Toxin
H3V42_RS21540 4508252..4508521 - 270 WP_159365511.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H3V42_RS21545 4508571..4508783 - 213 WP_185703817.1 hypothetical protein -
H3V42_RS21550 4508770..4509009 - 240 WP_185703819.1 AlpA family phage regulatory protein -
H3V42_RS21555 4509460..4509999 + 540 WP_185703821.1 AAA family ATPase -
H3V42_RS21560 4510525..4510743 + 219 Protein_4256 DUF3380 domain-containing protein -
H3V42_RS21565 4510740..4511249 + 510 WP_185703823.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-62)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15904.05 Da        Isoelectric Point: 4.5542

>T170031 WP_185703815.1 NZ_CP060122:c4508255-4507824 [Sphingobium yanoikuyae]
MSFLLDTNIISEGAKPRPDPGVMDWLASVDEEELFLSVVSLAELRHGIERMDKGARQSGLDIWLTEQLAPRFEERLLSID
SVTADLWGRIVNRAQGAGRPMGAMDAFIAAHAQQHELTLVTRNISDFEATGIRLFNPWTEGKA

Download         Length: 432 bp

>T170031 NZ_CP077061:27163-27453 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10073.44 Da        Isoelectric Point: 8.8908

>AT170031 WP_159365511.1 NZ_CP060122:c4508521-4508252 [Sphingobium yanoikuyae]
MAVETHPDSWTVAQAKARLSEVIEKARREPQAITRHGKSAVVVVDAELWERVQRRQHRGSFADFLLTSPLRGSGLEVDRL
KDGVREIDL

Download         Length: 270 bp

>AT170031 NZ_CP077061:26925-27173 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References