Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3897869..3898503 Replicon chromosome
Accession NZ_CP060122
Organism Sphingobium yanoikuyae strain A3

Toxin (Protein)


Gene name vapC Uniprot ID T0IXY4
Locus tag H3V42_RS18640 Protein ID WP_021225100.1
Coordinates 3898114..3898503 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5B8CCM4
Locus tag H3V42_RS18635 Protein ID WP_031297643.1
Coordinates 3897869..3898117 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V42_RS18610 3892886..3893962 - 1077 WP_021225106.1 HlyD family efflux transporter periplasmic adaptor subunit -
H3V42_RS18615 3893959..3895428 - 1470 WP_040603655.1 efflux transporter outer membrane subunit -
H3V42_RS18620 3895511..3895954 - 444 WP_021225104.1 hypothetical protein -
H3V42_RS18625 3896055..3896783 - 729 WP_031297645.1 acetoacetyl-CoA reductase -
H3V42_RS18630 3897029..3897628 + 600 WP_084514710.1 TetR/AcrR family transcriptional regulator -
H3V42_RS18635 3897869..3898117 + 249 WP_031297643.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H3V42_RS18640 3898114..3898503 + 390 WP_021225100.1 type II toxin-antitoxin system VapC family toxin Toxin
H3V42_RS18645 3898503..3898835 + 333 WP_021225099.1 hypothetical protein -
H3V42_RS18650 3899439..3899855 - 417 Protein_3680 acetyl-CoA C-acyltransferase -
H3V42_RS18655 3900122..3901021 - 900 WP_140041722.1 AraC family transcriptional regulator -
H3V42_RS18660 3901141..3903282 + 2142 WP_185703445.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13953.80 Da        Isoelectric Point: 4.5908

>T170028 WP_021225100.1 NZ_CP060122:3898114-3898503 [Sphingobium yanoikuyae]
MILDTSALVAILYREPEAESFTQAIHNADACRISGATYVELSIVIENQLGSEGMRQAEAFFRRAGITIEPVTVEHGELAR
QAFLDFGKGRHKAGLNFGDCFSFALAKATGEPLLFKGNDFALTDLEAAA

Download         Length: 390 bp

>T170028 NZ_CP077061:c7391-7104 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9169.50 Da        Isoelectric Point: 9.6257

>AT170028 WP_031297643.1 NZ_CP060122:3897869-3898117 [Sphingobium yanoikuyae]
VSLNVKDPEAHRLARAIAQATGQSMTRVVTEALRECYARIERNKRKASVAELLAIADRAAVHVKRSYIEHGELLYDENGL
PK

Download         Length: 249 bp

>AT170028 NZ_CP077061:c7632-7381 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B8CAU4

Antitoxin

Source ID Structure
AlphaFold DB A0A5B8CCM4

References