Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1896095..1896792 Replicon chromosome
Accession NZ_CP060122
Organism Sphingobium yanoikuyae strain A3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H3V42_RS09325 Protein ID WP_185706496.1
Coordinates 1896361..1896792 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H3V42_RS09320 Protein ID WP_185706494.1
Coordinates 1896095..1896364 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V42_RS09295 1893219..1893521 - 303 WP_185706484.1 DUF1153 domain-containing protein -
H3V42_RS09300 1893738..1894682 + 945 WP_185706486.1 sensor domain-containing diguanylate cyclase -
H3V42_RS09305 1894853..1895140 + 288 WP_185706488.1 hypothetical protein -
H3V42_RS09310 1895585..1895845 + 261 WP_185706490.1 AlpA family phage regulatory protein -
H3V42_RS09315 1895832..1896044 + 213 WP_185706492.1 hypothetical protein -
H3V42_RS09320 1896095..1896364 + 270 WP_185706494.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H3V42_RS09325 1896361..1896792 + 432 WP_185706496.1 type II toxin-antitoxin system VapC family toxin Toxin
H3V42_RS09330 1896792..1898432 + 1641 WP_185706498.1 recombinase family protein -
H3V42_RS09335 1898450..1899553 - 1104 WP_010335434.1 Gfo/Idh/MocA family oxidoreductase -
H3V42_RS09340 1899555..1899785 - 231 WP_004209482.1 dihydrolipoamide acyltransferase -
H3V42_RS09345 1899904..1900557 - 654 WP_010335435.1 carboxymuconolactone decarboxylase family protein -
H3V42_RS09350 1900580..1900882 - 303 WP_185706500.1 DUF1330 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-67)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15872.05 Da        Isoelectric Point: 4.6456

>T170025 WP_185706496.1 NZ_CP060122:1896361-1896792 [Sphingobium yanoikuyae]
MSFLLDTNIISEGARPRPDPGVMEWLASMDEEELFLSVVSVAELRHGIERMDKGARQAGLDIWLTEQLAPRFEDRLLSID
SVTADLWGRIVARAQGAGRPIGAMDAFIAAHAQQHQLTLVTRNISDFEATGIRLFNPWTEGKA

Download         Length: 432 bp

>T170025 NZ_CP077061:c1760-1458 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10015.40 Da        Isoelectric Point: 10.2846

>AT170025 WP_185706494.1 NZ_CP060122:1896095-1896364 [Sphingobium yanoikuyae]
MAVETHPDSWTVAQAKARLSEVIEKARREPQAITRHGKSAVVVVDAGLWERVQRRQHRGSFADFLLTSPLRGSGLEVERL
KDGVREIDL

Download         Length: 270 bp

>AT170025 NZ_CP077061:c2005-1748 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References