Detailed information of TA system TA170024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 792378..792933
• Replicon: chromosome
• Accession: NZ_CP060122
• Organism: Sphingobium yanoikuyae strain A3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H3V42_RS03815
• Protein ID: WP_010337578.1
• Coordinates: 792378..792686 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A291MUN4
• Locus tag: H3V42_RS03820
• Protein ID: WP_010337577.1
• Coordinates: 792688..792933 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3V42_RS03800	787964..789361	+	1398	WP_010337581.1	helix-turn-helix transcriptional regulator	-
H3V42_RS03805	789513..790790	+	1278	WP_010337580.1	MFS transporter	-
H3V42_RS03810	790857..792371	+	1515	WP_010337579.1	peptidase S10	-
H3V42_RS03815	792378..792686	-	309	WP_010337578.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3V42_RS03820	792688..792933	-	246	WP_010337577.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
H3V42_RS03825	793081..794457	+	1377	WP_010337576.1	amidohydrolase	-
H3V42_RS03830	794454..795440	-	987	WP_010337575.1	phosphatase PAP2 family protein	-
H3V42_RS03835	795528..796718	-	1191	WP_037525211.1	chromate efflux transporter	-
H3V42_RS03840	796891..797604	-	714	WP_010337573.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11841.53 Da
• Isoelectric Point: 6.4860

>T170024 WP_010337578.1 NZ_CP060122:c792686-792378 [Sphingobium yanoikuyae]
MARYRLTRAASDDIAAIFIDGIERFGLVQADLYHAGLAAAFDLIAEYPFAVRLREEIVPPVRVRHYRAHLILYDLVEDSR
PLILRVRHGREDWQAREEGPDR

Nucleotide

• Length: 309 bp

>T170024 NZ_CP076863:4952803-4953213 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGAAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9258.53 Da
• Isoelectric Point: 7.2027

>AT170024 WP_010337577.1 NZ_CP060122:c792933-792688 [Sphingobium yanoikuyae]
MATMNISLPDPMKNWVEAQTATGRYSNASDYVRDLIRRDQERLAKVAHMQMLVDEARQGGISDETMEDIRVRALHQAGLK
R

Nucleotide

• Length: 246 bp

>AT170024 NZ_CP076863:4952556-4952822 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A291MUN4