Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3289227..3289879 Replicon chromosome
Accession NZ_CP060120
Organism Janibacter sp. YB324

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7A72_RS16165 Protein ID WP_084451100.1
Coordinates 3289227..3289619 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7A72_RS16170 Protein ID WP_185221154.1
Coordinates 3289616..3289879 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7A72_RS16140 3285089..3285481 - 393 WP_185221151.1 hypothetical protein -
H7A72_RS16145 3285613..3286227 + 615 WP_185221152.1 hypothetical protein -
H7A72_RS16150 3286314..3287072 - 759 WP_185222428.1 MerR family transcriptional regulator -
H7A72_RS16155 3287269..3287700 + 432 WP_084451101.1 hypothetical protein -
H7A72_RS16160 3287697..3289217 + 1521 WP_185221153.1 multicopper oxidase family protein -
H7A72_RS16165 3289227..3289619 - 393 WP_084451100.1 type II toxin-antitoxin system VapC family toxin Toxin
H7A72_RS16170 3289616..3289879 - 264 WP_185221154.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H7A72_RS16175 3290017..3291183 + 1167 WP_185221155.1 phytanoyl-CoA dioxygenase family protein -
H7A72_RS16180 3291193..3291963 + 771 WP_185221156.1 SDR family oxidoreductase -
H7A72_RS16185 3291965..3292990 + 1026 WP_072625985.1 Gfo/Idh/MocA family oxidoreductase -
H7A72_RS16190 3293012..3294235 - 1224 WP_185221157.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14076.92 Da        Isoelectric Point: 4.5860

>T169997 WP_084451100.1 NZ_CP060120:c3289619-3289227 [Janibacter sp. YB324]
VIVDTSVLVCIHDGEPEARRYLEVLLDEPSPRISAGSLLEASIVLDARQPLRTSRRLDRLVADLRLDVVPVDEQQVSAAR
AAYRDYGKGSGHAAGLNFGDCFAYALAATTGEPLLFKGDDFTHTDVLPVV

Download         Length: 393 bp

>T169997 NZ_CP076851:c2476350-2475790 [Mycobacterium avium subsp. hominissuis]
GTGAGCGAAGCCCTCGATGAAGGGCTCGTCCAACGCATCGACGCACGCGGCACAACAGAGTGGTCGGGAACGTGCTACCG
CTATACCGGCGCGCATCGTGACGCCTTGTCCGGGGAGGGGGCACGCAGATTCGGAGGCAGGTGGAATCCACCCCTACTTT
TTCCGGCGATCTATCTTGCTGACTCCGCCCAGGCCTGCATGGTTGAGGTGGAACGGGTAGCGCAAGCGGCCTCAACGACC
GCAGAGAAGATGCTCGAGGCGACCTACCGACTGCACACCATCGATGTAACGGACCTGGCCGTTCTCGATCTGCGCACCCC
AGACGCCCGCGAAGCGGTAGGGCTCGAGAACGATGACATCTACGGCGATGACTGGTCAGCGTGCCAGGCGGTAGGGCACG
CAGCATGGTTCCTGCACATGCAAGGCGTCCTGGTGCCCGCGGCGGGCGGTGTCGGCGTAGTTGTCACCGCGTATGAACAA
CGAACCCGTCCAGGTCAACTACAGCTGCGACAAAGCGTCGATCTGACGCCTGTCCTTTACCAAGAACTCCGAGCCACCTA
A

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9933.00 Da        Isoelectric Point: 4.9057

>AT169997 WP_185221154.1 NZ_CP060120:c3289879-3289616 [Janibacter sp. YB324]
MGLNIKNQRVHDLAREVAQRTGTTQTSAIEEALQRRLEALRAADDDDARRRRLLRLMDEIESDTTAADRARTAQIQEELY
DDRGLPA

Download         Length: 264 bp

>AT169997 NZ_CP076851:c2476688-2476347 [Mycobacterium avium subsp. hominissuis]
ATGGGAGTAAACGCGCTCGCCTCGACGGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGCGAAAT
CGTCGATGCCTCCCCGCGCTCCGTGGCGCGATGGACCGCAGGTCAGGTAGTTCCTCAACGTCTCAACAAGCAACGACTAA
TCGAGCTGGCCTATGTCGCCGACGCCCTGGCGGAAGTGTTGCCGCGTGACCAGGCGAATGTGTGGATGTTTTCGCCGAAT
CGATTACTAGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAATACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References