Detailed information of TA system TA169996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3160525..3161129
• Replicon: chromosome
• Accession: NZ_CP060120
• Organism: Janibacter sp. YB324

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7G7HSU6
• Locus tag: H7A72_RS15565
• Protein ID: WP_072625875.1
• Coordinates: 3160525..3160905 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H7A72_RS15570
• Protein ID: WP_084449641.1
• Coordinates: 3160902..3161129 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7A72_RS15535	3156341..3157283	+	943	Protein_3049	LysR family transcriptional regulator	-
H7A72_RS15540	3157280..3157870	-	591	WP_072625870.1	DUF998 domain-containing protein	-
H7A72_RS15545	3157867..3158193	-	327	WP_159451129.1	hypothetical protein	-
H7A72_RS15550	3158190..3159119	-	930	WP_072625872.1	alpha/beta hydrolase	-
H7A72_RS15555	3159212..3159847	+	636	WP_072625873.1	DUF3105 domain-containing protein	-
H7A72_RS15560	3159844..3160473	+	630	WP_084449642.1	DUF305 domain-containing protein	-
H7A72_RS15565	3160525..3160905	-	381	WP_072625875.1	type II toxin-antitoxin system VapC family toxin	Toxin
H7A72_RS15570	3160902..3161129	-	228	WP_084449641.1	antitoxin	Antitoxin
H7A72_RS15575	3161183..3162154	+	972	WP_185221097.1	threonine/serine dehydratase	-
H7A72_RS15580	3162145..3162417	-	273	WP_185221098.1	hypothetical protein	-
H7A72_RS15585	3162545..3165934	+	3390	WP_185221099.1	exodeoxyribonuclease V subunit gamma	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13446.48 Da
• Isoelectric Point: 4.8616

>T169996 WP_072625875.1 NZ_CP060120:c3160905-3160525 [Janibacter sp. YB324]
VIVVDASAMVEALVGRAPDPRLLDALAGVVEAPQHLDVEVLSVLRGLTLGAKLPAARAEEALGAYLDLDITRRDVAPFAR
RVWSLRHQYTSYDAAYLALAEGLDAPLYTCDRKLAAGGHTAEVVVI

Nucleotide

• Length: 381 bp

>T169996 NZ_CP076851:2400773-2401351 [Mycobacterium avium subsp. hominissuis]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCATGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTCGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8288.35 Da
• Isoelectric Point: 5.0644

>AT169996 WP_084449641.1 NZ_CP060120:c3161129-3160902 [Janibacter sp. YB324]
MPTLYIRDVPDDVAETLKQRAAADGQSLSAYVAGALLRLAERPTNAEVVERLRQVDRTLAPASEEIVSTLHESRR

Nucleotide

• Length: 228 bp

>AT169996 NZ_CP076851:2400353-2400742 [Mycobacterium avium subsp. hominissuis]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGACCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGACGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A7G7HSU6