Detailed information of TA system TA169995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1630888..1631492
• Replicon: chromosome
• Accession: NZ_CP060120
• Organism: Janibacter sp. YB324

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7G7HX65
• Locus tag: H7A72_RS07860
• Protein ID: WP_072624583.1
• Coordinates: 1631094..1631492 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H7A72_RS07855
• Protein ID: WP_185222190.1
• Coordinates: 1630888..1631097 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7A72_RS07830	1626800..1627621	-	822	WP_185222332.1	SDR family oxidoreductase	-
H7A72_RS07835	1627771..1628781	-	1011	WP_185222187.1	TerC/Alx family metal homeostasis membrane protein	-
H7A72_RS07840	1628956..1629333	-	378	WP_185222188.1	hypothetical protein	-
H7A72_RS07845	1629314..1630366	-	1053	WP_185222189.1	FAD-dependent oxidoreductase	-
H7A72_RS07850	1630538..1630867	+	330	WP_084451932.1	single-stranded DNA-binding protein	-
H7A72_RS07855	1630888..1631097	+	210	WP_185222190.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
H7A72_RS07860	1631094..1631492	+	399	WP_072624583.1	PIN domain nuclease	Toxin
H7A72_RS07865	1631512..1631877	-	366	WP_185222191.1	hypothetical protein	-
H7A72_RS07870	1631981..1632901	+	921	WP_185222192.1	dihydrodipicolinate synthase family protein	-
H7A72_RS07875	1632898..1633422	+	525	WP_072624586.1	hypothetical protein	-
H7A72_RS07880	1633497..1633742	+	246	WP_185222193.1	hypothetical protein	-
H7A72_RS07885	1633752..1634192	+	441	WP_185222194.1	hypothetical protein	-
H7A72_RS07890	1634287..1634832	-	546	WP_185222195.1	hypothetical protein	-
H7A72_RS07895	1634989..1636059	-	1071	WP_185222196.1	FUSC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-38)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14518.57 Da
• Isoelectric Point: 6.9687

>T169995 WP_072624583.1 NZ_CP060120:1631094-1631492 [Janibacter sp. YB324]
VTLVDTSVWVEYLRGTDSPSTRYVRERLGSDLFTTEPVLMELLAGARHGASTARLERLLLSQSWARLKPALDHRGAVDVF
HACRSDGRPIRSINDCLIAAIALRVDIAVAHRDSDFEHIAAVTGLTVVDLRG

Nucleotide

• Length: 399 bp

>T169995 NZ_CP076851:2103700-2104107 [Mycobacterium avium subsp. hominissuis]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGC
GCGAATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCG
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCAGCCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTCGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTCTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7763.83 Da
• Isoelectric Point: 4.2092

>AT169995 WP_185222190.1 NZ_CP060120:1630888-1631097 [Janibacter sp. YB324]
MGRTNIEIDDDLIAEAMRRYGLATKREAVDFALRRLVGPVMTREEMLAMEGSGWEGDLDQLRGDPVEPV

Nucleotide

• Length: 210 bp

>AT169995 NZ_CP076851:2103443-2103703 [Mycobacterium avium subsp. hominissuis]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Structures

Toxin

• AlphaFold DB: A0A7G7HX65