Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4260727..4261381 Replicon chromosome
Accession NZ_CP060117
Organism Shigella sonnei strain UKMCC_1015

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag HYI41_RS21450 Protein ID WP_000244777.1
Coordinates 4260727..4261134 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HYI41_RS21455 Protein ID WP_000354046.1
Coordinates 4261115..4261381 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYI41_RS21430 (4256684) 4256684..4258417 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
HYI41_RS21435 (4258423) 4258423..4259133 - 711 WP_140046308.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HYI41_RS21440 (4259158) 4259158..4260054 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HYI41_RS21445 (4260166) 4260166..4260687 + 522 WP_001055874.1 flavodoxin FldB -
HYI41_RS21450 (4260727) 4260727..4261134 - 408 WP_000244777.1 protein YgfX Toxin
HYI41_RS21455 (4261115) 4261115..4261381 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HYI41_RS21460 (4261624) 4261624..4262604 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
HYI41_RS21465 (4262800) 4262800..4263459 - 660 WP_000250274.1 hemolysin III family protein -
HYI41_RS21470 (4263623) 4263623..4263934 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
HYI41_RS21475 (4263979) 4263979..4265412 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
HYI41_RS21480 (4265469) 4265469..4266212 - 744 WP_000951938.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T169993 WP_000244777.1 NZ_CP060117:c4261134-4260727 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T169993 NZ_CP076851:1086507-1086968 [Mycobacterium avium subsp. hominissuis]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGCTCGGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCAGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGCTCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT169993 WP_000354046.1 NZ_CP060117:c4261381-4261115 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT169993 NZ_CP076851:1086315-1086503 [Mycobacterium avium subsp. hominissuis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGTTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACTGGCGACCAGCAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References