Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2706698..2707182 Replicon chromosome
Accession NZ_CP060117
Organism Shigella sonnei strain UKMCC_1015

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag HYI41_RS13460 Protein ID WP_014334020.1
Coordinates 2706698..2706988 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag HYI41_RS13465 Protein ID WP_005142544.1
Coordinates 2706988..2707182 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYI41_RS13420 (2702494) 2702494..2702685 - 192 WP_001090204.1 DUF1482 family protein -
HYI41_RS13425 (2702682) 2702682..2702870 - 189 WP_000449206.1 cell division inhibition protein DicB -
HYI41_RS13430 (2702881) 2702881..2702976 - 96 Protein_2613 transcriptional regulator -
HYI41_RS13435 (2703033) 2703033..2703730 + 698 WP_237158186.1 IS1-like element IS1A family transposase -
HYI41_RS13440 (2703724) 2703724..2704512 - 789 WP_000935603.1 Rha family phage regulatory protein -
HYI41_RS13445 (2705045) 2705045..2705742 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
HYI41_RS13450 (2705890) 2705890..2706255 - 366 WP_024174355.1 hypothetical protein -
HYI41_RS13455 (2706267) 2706267..2706419 - 153 WP_000379558.1 DUF1391 family protein -
HYI41_RS13460 (2706698) 2706698..2706988 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYI41_RS13465 (2706988) 2706988..2707182 - 195 WP_005142544.1 hypothetical protein Antitoxin
HYI41_RS13470 (2707202) 2707202..2707687 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
HYI41_RS13475 (2707814) 2707814..2708077 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
HYI41_RS13480 (2708074) 2708074..2708499 + 426 WP_000693826.1 toxin YdaT family protein -
HYI41_RS13485 (2708571) 2708571..2709635 + 1065 WP_001262380.1 hypothetical protein -
HYI41_RS13490 (2709642) 2709642..2710388 + 747 WP_000788740.1 ATP-binding protein -
HYI41_RS13495 (2710410) 2710410..2710775 + 366 Protein_2626 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / rhs/PAAR / rhs/PAAR / vgrG/tssI 2607481..2840399 232918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T169989 WP_014334020.1 NZ_CP060117:c2706988-2706698 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T169989 NZ_CP076843:c1747462-1747253 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT169989 WP_005142544.1 NZ_CP060117:c2707182-2706988 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT169989 NZ_CP076843:c1747767-1747474 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References