Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1410835..1411672 Replicon chromosome
Accession NZ_CP060117
Organism Shigella sonnei strain UKMCC_1015

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag HYI41_RS06795 Protein ID WP_000227784.1
Coordinates 1410835..1411377 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag HYI41_RS06800 Protein ID WP_001297137.1
Coordinates 1411361..1411672 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYI41_RS06765 (1405899) 1405899..1406390 + 492 WP_001138904.1 nucleotide binding protein YajQ -
HYI41_RS06770 (1406518) 1406518..1407882 - 1365 WP_001000971.1 MFS transporter -
HYI41_RS06775 (1408001) 1408001..1408698 + 698 WP_237158176.1 IS1-like element IS1A family transposase -
HYI41_RS06780 (1409067) 1409067..1409465 + 399 Protein_1311 SEL1-like repeat protein -
HYI41_RS06790 (1410213) 1410213..1410779 + 567 Protein_1313 SEL1-like repeat protein -
HYI41_RS06795 (1410835) 1410835..1411377 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
HYI41_RS06800 (1411361) 1411361..1411672 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
HYI41_RS06805 (1411857) 1411857..1412747 - 891 WP_000971327.1 heme o synthase -
HYI41_RS06810 (1412759) 1412759..1413088 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
HYI41_RS06815 (1413088) 1413088..1413702 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
HYI41_RS06820 (1413692) 1413692..1415683 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
HYI41_RS06825 (1415705) 1415705..1416652 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T169979 WP_000227784.1 NZ_CP060117:c1411377-1410835 [Shigella sonnei]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T169979 NZ_CP076838:c3776799-3776449 [Leclercia pneumoniae]
ATGGTGAGGGCGTTGACGTACGATCGGGGCGATATCGTGCTGGTCAACTTTTCTCCTGCAAACGGCCATGAACAGCAAGG
CGCTGGTCGGCCAGCGCTGGTGCTTTCCCTCAGTACGTTTAATCAGACCGGTATGGTGCTGGTGGCCCCCATTACGCAGG
GCGGTAGTTATGCCCGCTACGCCGGGTTTGCCGTGCCTGTAAGCTGCGAAGAGGGGGATGTGCAGGGGGCCGTGCTGGTT
AATCAGCTCCGGATGATGGATCTGCATGCCCGGCAGGCGAAAAAGATCGCCATCGCAACGGATGAGGTCGTAGAGGATGC
CCTGCTGCGTCTGCAGGCCATTATCGACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT169979 WP_001297137.1 NZ_CP060117:c1411672-1411361 [Shigella sonnei]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT169979 NZ_CP076838:c3777044-3776793 [Leclercia pneumoniae]
ATGCGTATTACGATTAAGAAATGGGGAAATAGCGCTGGGGTCATCATCCCCGGCGCCATCATGAAAGAACTTAACATGCA
GGTGGGACAGAGTATGGAAGCTCAGGTCGTTGATAATCAGGTGGTACTTAAACCTCTCAGTAAGCGTTACACCCTTGAAG
AACTGCTGGCGCAGTGCGATCCGAACGCGGCGCCCGCCACGGAAGATGAACTGTGGGGCAATGCAGGGCCGATGGGCAAT
GAAGTATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References