Detailed information of TA system TA169976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 330733..331247
• Replicon: chromosome
• Accession: NZ_CP060115
• Organism: Fusobacterium hwasookii strain KCOM 1253

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H5V38_RS01395
• Protein ID: WP_029494261.1
• Coordinates: 330733..330990 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: U7TQU0
• Locus tag: H5V38_RS01400
• Protein ID: WP_005919458.1
• Coordinates: 330990..331247 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5V38_RS01370	326200..327117	-	918	Protein_259	hypothetical protein	-
H5V38_RS01375	327207..327769	-	563	Protein_260	hypothetical protein	-
H5V38_RS01380	327766..328249	-	484	Protein_261	hypothetical protein	-
H5V38_RS01385	328570..329307	-	738	WP_029494262.1	tRNA pseudouridine(38-40) synthase TruA	-
H5V38_RS01390	329540..330616	-	1077	WP_029490883.1	DHH family phosphoesterase	-
H5V38_RS01395	330733..330990	-	258	WP_029494261.1	Txe/YoeB family addiction module toxin	Toxin
H5V38_RS01400	330990..331247	-	258	WP_005919458.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H5V38_RS01405	331367..332440	-	1074	WP_029490884.1	glycerophosphodiester phosphodiesterase	-
H5V38_RS01410	332483..333481	-	999	WP_029494260.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
H5V38_RS01415	333506..333979	-	474	WP_029490886.1	OmpH family outer membrane protein	-
H5V38_RS01420	334019..336112	-	2094	WP_029494259.1	outer membrane protein assembly factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10060.57 Da
• Isoelectric Point: 9.7287

>T169976 WP_029494261.1 NZ_CP060115:c330990-330733 [Fusobacterium hwasookii]
MLLTWTDFASKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Nucleotide

• Length: 258 bp

>T169976 NZ_CP076838:c1992306-1991815 [Leclercia pneumoniae]
GTGGGAAAAGTAACGGCTCCAGTACCATTGAATTCGTCACATATTCTCGCTGAATTTCACTGTGGTGAAGCTGCACTGGA
CGAATGGATTAAGCACCGGGGGTTAAAAAATCAATCCATGGGAGCTGCAAGGACATTTGTGGTATGCCGGGGCAACGCGT
CTCAGGTGATTGGGTTTTATTCTCTCGCGACCGGTAGCGTCACCCATGCTGTTGCACCGGGAAGCCTGCGCAGGAATATG
CCCGATCCGGTCCCCGTCATCATTCTGGCCCGGCTTGCCGTTGATGCGAGTTTTCACAGCAAAGGACTCGGTGCTGATTT
ACTCCATGACGCCGTCTTACGCTGCTGCCGGGTGGCTGAGAACATTGGCGTACGGGCCATTATGGTTCATGCTATTTCCG
ACCGCGCCAGGCAGTTTTACATCCATCACGGATTCACCCCTTCGCAAACGCAGGAGAGAACCTTATTCCTGCGATTGCCG
ATCATAACTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10110.43 Da
• Isoelectric Point: 4.7022

>AT169976 WP_005919458.1 NZ_CP060115:c331247-330990 [Fusobacterium hwasookii]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Nucleotide

• Length: 258 bp

>AT169976 NZ_CP076838:c1992581-1992294 [Leclercia pneumoniae]
TTGCTATACAAAGGAGGAAGTATGAAATCTGATGTTCAGCTTAATATCCGGGCAAAAGAAGCGCAGCGAGCCCTGATTGA
TGCTGCCGCTGAGATTCTCCATAAATCACGCACCGATTTTATCCTGGAGATGGCCTGCCAGGCAGCTGAGAACGTCATCC
TTGACCGCCGGATGTTTAATCTTAACGATGAACAATATGCCGAATTTATCGAGATGCTGGATGCCCCGGTGACTGCTAAT
CCGGCGATGGATAAACTCCTGGCGAGAAAACCGCAGTGGGAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0S2ZLE4