Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 328145..328659 Replicon chromosome
Accession NZ_CP060112
Organism Fusobacterium hwasookii strain KCOM 1249

Toxin (Protein)


Gene name relB Uniprot ID X7SD51
Locus tag H5V36_RS01540 Protein ID WP_005919455.1
Coordinates 328402..328659 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag H5V36_RS01535 Protein ID WP_005919458.1
Coordinates 328145..328402 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H5V36_RS01520 324368..326461 + 2094 WP_185167292.1 outer membrane protein assembly factor -
H5V36_RS01525 326501..326974 + 474 Protein_275 OmpH family outer membrane protein -
H5V36_RS01530 326998..327996 + 999 WP_185167293.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
H5V36_RS01535 328145..328402 + 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H5V36_RS01540 328402..328659 + 258 WP_005919455.1 Txe/YoeB family addiction module toxin Toxin
H5V36_RS01545 328776..329852 + 1077 WP_185167294.1 DHH family phosphoesterase -
H5V36_RS01550 330085..330822 + 738 WP_005919450.1 tRNA pseudouridine(38-40) synthase TruA -
H5V36_RS01555 330979..331371 + 393 WP_032879888.1 hypothetical protein -
H5V36_RS01560 331560..331892 + 333 WP_005919445.1 hypothetical protein -
H5V36_RS01565 331932..333302 + 1371 WP_005919443.1 ankyrin repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10159.71 Da        Isoelectric Point: 9.7287

>T169975 WP_005919455.1 NZ_CP060112:328402-328659 [Fusobacterium hwasookii]
MLLTWTDFAWKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Download         Length: 258 bp

>T169975 NZ_CP076838:1630389-1630492 [Leclercia pneumoniae]
GCAAGGCGACTTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT169975 WP_005919458.1 NZ_CP060112:328145-328402 [Fusobacterium hwasookii]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT169975 NZ_CP076838:c1630505-1630324 [Leclercia pneumoniae]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTTAAGTCGCCTTGCACTATAAGAATAGATGACAGCGCCAGGTTTTCCAGTCCGCATC
AAAAGTGGTCAGAAAAAAAGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2ZLL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References