Detailed information of TA system TA169973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 4885657..4886476
• Replicon: chromosome
• Accession: NZ_CP060111
• Organism: Klebsiella michiganensis strain AKKL-001

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: H5403_RS23015
• Protein ID: WP_004110819.1
• Coordinates: 4886219..4886476 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: H5403_RS23010
• Protein ID: WP_185219606.1
• Coordinates: 4885657..4886208 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5403_RS22995	4881028..4882425	+	1398	WP_185219605.1	MFS transporter	-
H5403_RS23000	4882548..4883888	+	1341	WP_103815323.1	carbohydrate porin	-
H5403_RS23005	4884011..4885639	-	1629	WP_185220208.1	SAM-dependent methyltransferase	-
H5403_RS23010	4885657..4886208	-	552	WP_185219606.1	N-acetyltransferase	Antitoxin
H5403_RS23015	4886219..4886476	-	258	WP_004110819.1	YjhX family toxin	Toxin
H5403_RS23020	4887152..4888336	+	1185	WP_014228054.1	mannonate dehydratase	-
H5403_RS23025	4888410..4889885	+	1476	WP_014228053.1	fructuronate reductase	-
H5403_RS23030	4890024..4890800	+	777	WP_185219607.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T169973 WP_004110819.1 NZ_CP060111:c4886476-4886219 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T169973 NZ_CP076838:197243-197611 [Leclercia pneumoniae]
ATGACGCTGCAATTTATCTCAGCGGAAGAGATAGTGCTGTTTCACGACAAGCTGCTTAGCGTGACGCCGGGCGTTGCGGG
AATGCCGGATCCAGGCCGGGCGGAAGCCCTGCTGTATCGCGTGCTGAATAAGTACGAATACGAAGGCGTTACCGATGTCT
GGATGCTGGCGGCGATGCACCTGCTGGCTATCTCTCGCGGTCACATCTTCAATGACGGCAATAAGCGAACGGCTTTGTTT
ATTACCCTGCTGTTTCTCAAACGTAATGGTATTTCGTTAAAGGCCAATCCCGATTATGTGGATATGACCGTTGAGGCAGC
GGCAGGACGTTTGACGCTTGACGAGGTTGTCCAGCGTCTACGTTGTTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19976.78 Da
• Isoelectric Point: 6.4897

>AT169973 WP_185219606.1 NZ_CP060111:c4886208-4885657 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHSIEQLKAMGSQAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRAGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT169973 NZ_CP076838:197025-197246 [Leclercia pneumoniae]
ATGCGTACAATGAACTATAGCGAAGCCCGGCAGAATCTTGCCTCCGCGCTCGAGTCCGCGGCAGCAGGAACGCCAGTCAC
TATTTCACGTCGTGGTCATAAGTCTGCAGTGATCATCAGTGTGGAAGAGTTTGAGCGTTATCAGACGGCAAAGCTCGACG
CAGAGTTTGACGCCATCATGGGTATTCATGGCAGCGAAATCAGGGAGCTGGCTGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2