Detailed information of TA system TA169961

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1332656..1333439
• Replicon: chromosome
• Accession: NZ_CP060111
• Organism: Klebsiella michiganensis strain AKKL-001

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H5403_RS06375
• Protein ID: WP_010434197.1
• Coordinates: 1332656..1333030 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: H5403_RS06380
• Protein ID: WP_024274583.1
• Coordinates: 1333080..1333439 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5403_RS06355	1328328..1328561	-	234	WP_004132711.1	hypothetical protein	-
H5403_RS06360	1328971..1329243	+	273	WP_016247220.1	hypothetical protein	-
H5403_RS06365	1329446..1330354	+	909	WP_024274585.1	kdo(2)-lipid IV(A) palmitoleoyltransferase	-
H5403_RS06370	1331128..1332117	+	990	WP_010434201.1	glycosyltransferase	-
H5403_RS06375	1332656..1333030	-	375	WP_010434197.1	TA system toxin CbtA family protein	Toxin
H5403_RS06380	1333080..1333439	-	360	WP_024274583.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H5403_RS06385	1333462..1333683	-	222	WP_010434193.1	DUF987 domain-containing protein	-
H5403_RS06390	1333697..1334179	-	483	WP_024274581.1	DNA repair protein RadC	-
H5403_RS06395	1334176..1334409	-	234	WP_010434188.1	hypothetical protein	-
H5403_RS06400	1334420..1334899	-	480	WP_010434186.1	antirestriction protein	-
H5403_RS06405	1334978..1335799	-	822	WP_185219886.1	DUF945 domain-containing protein	-
H5403_RS06410	1335910..1336122	-	213	WP_010434180.1	hypothetical protein	-
H5403_RS06415	1336203..1336562	-	360	WP_010434179.1	hypothetical protein	-
H5403_RS06420	1336617..1337081	-	465	WP_024274580.1	hypothetical protein	-
H5403_RS06425	1337359..1338216	-	858	WP_010434177.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1313452..1359653	46201

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13977.96 Da
• Isoelectric Point: 9.6955

>T169961 WP_010434197.1 NZ_CP060111:c1333030-1332656 [Klebsiella michiganensis]
MQIHSLFLQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLYDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSLDILRARKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 375 bp

>T169961 NZ_CP076822:c7461-7141 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13469.67 Da
• Isoelectric Point: 7.7511

>AT169961 WP_024274583.1 NZ_CP060111:c1333439-1333080 [Klebsiella michiganensis]
MKKATRVINHNITEPWWGLRRNITPCFGARLVQEGNHLHYLADRASIAGTFNDADLRHLDQVFPVLMKQMELMLASSELT
PRIQRCITLHVKGLICEADTLGSCGYLYIVIYPASVTTE

Nucleotide

• Length: 360 bp

>AT169961 NZ_CP076822:c7148-6876 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA