Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 388234..388861 Replicon chromosome
Accession NZ_CP060096
Organism Aceticella autotrophica strain 3443-3Ac

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ACETAC_RS01705 Protein ID WP_284681026.1
Coordinates 388511..388861 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ACETAC_RS01700 Protein ID WP_284680351.1
Coordinates 388234..388509 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACETAC_RS01680 (ACETAC_01670) 383942..384304 + 363 WP_284680348.1 DUF6514 family protein -
ACETAC_RS01685 (ACETAC_01675) 384404..385936 + 1533 WP_284680349.1 NAD(P)H-hydrate dehydratase -
ACETAC_RS01690 (ACETAC_01680) 385949..386929 + 981 WP_284680350.1 outer membrane lipoprotein carrier protein LolA -
ACETAC_RS01695 (ACETAC_01685) 386980..388146 + 1167 WP_284681025.1 alanine racemase -
ACETAC_RS01700 (ACETAC_01690) 388234..388509 + 276 WP_284680351.1 ribbon-helix-helix protein, CopG family Antitoxin
ACETAC_RS01705 (ACETAC_01695) 388511..388861 + 351 WP_284681026.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ACETAC_RS01710 (ACETAC_01700) 388932..389348 + 417 WP_284680352.1 hypothetical protein -
ACETAC_RS01715 (ACETAC_01705) 389463..391493 + 2031 WP_284680353.1 DUF5693 family protein -
ACETAC_RS01720 (ACETAC_01710) 391490..392584 + 1095 WP_284680354.1 polysaccharide pyruvyl transferase CsaB -
ACETAC_RS01725 (ACETAC_01715) 392581..393306 + 726 WP_284680355.1 WecB/TagA/CpsF family glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12900.98 Da        Isoelectric Point: 6.4705

>T169956 WP_284681026.1 NZ_CP060096:388511-388861 [Aceticella autotrophica]
MVIKRGDILYADLSPVIGSEQGGVRPVLVIQNDIGNKYSPTVIVSAITSQINKAKLPTHVEINGTEFGLNKDSVILLEQI
RTIDKKRLREKIGHFDQEMMDKVNEALQISLGLIDF

Download         Length: 351 bp

>T169956 NZ_CP076817:c1713701-1713312 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAGAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10788.66 Da        Isoelectric Point: 8.4827

>AT169956 WP_284680351.1 NZ_CP060096:388234-388509 [Aceticella autotrophica]
VGETKRILVSLPESLLEEVDILAAMENRNRSEFIREAMRLYIRERKKMKIRESMKKGYLEMGTINAELAEMSLTAENECF
LRYERKLKKCD

Download         Length: 276 bp

>AT169956 NZ_CP076817:c1713965-1713708 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References